Soldevila-Matías Pau, Sánchez-Ortí Joan Vicent, Correa-Ghisays Patricia, Balanzá-Martínez Vicent, Selva-Vera Gabriel, Sanchis-Sanchis Roberto, Iglesias-García Néstor, Monfort-Pañego Manuel, Tomás-Martínez Pilar, Victor Víctor M, Crespo-Facorro Benedicto, Valenzuela Constanza San Martin, Climent-Sánchez José Antonio, Corral-Márquez Rosana, Fuentes-Durá Inmaculada, Tabarés-Seisdedos Rafael
Faculty of Psychology, University of Valencia, Valencia, Spain.
INCLIVA-Health Research Institute, Valencia, Spain.
PLoS One. 2025 Jan 3;20(1):e0313759. doi: 10.1371/journal.pone.0313759. eCollection 2025.
This study aimed to evaluate the predictive validity and discriminatory ability of clinical outcomes, inflammatory activity, oxidative and vascular damage, and metabolic mechanisms for detecting significant improve maximum heart rate after physical activity training in individuals with psychiatric disorders and obesity comorbid using a longitudinal design and transdiagnostic perspective.
Patients with major depressive disorder, bipolar disorder and, schizophrenia and with comorbid obesity (n = 29) were assigned to a 12-week structured physical exercise program. Peripheral blood biomarkers of inflammation, oxidative stress, vascular mechanisms, and metabolic activity, as well as neurocognitive and functional performance were assessed twice, before and after intervention. Maximum heart rate was considered a marker of effectiveness of physical activity. Mixed one-way analysis of variance and linear regression analyses were performed.
Individuals with psychiatric disorders and comorbid obesity exhibited an improvement in cognition, mood symptoms and body mass index, increase anti-inflammatory activity together with enhancement of the oxidative and cardiovascular mechanisms after physical activity training (p<0.05 to 0.0001; d = 0.47 to 1.63). A better clinical outcomes along with regulation of inflammatory, oxidative, and cardiovascular mechanisms were critical for predicting significant maximum heart rate variation over time (χ2 = 32.2 to 39.0, p < 0.0001).
The regulation of the anti-inflammatory mechanisms may be essential for maintained of healthy physical activity across psychiatric disorders and obesity. Likewise, inflammatory activity, oxidative stress, vascular and cardio-metabolic mechanisms may be a useful to identify individuals at greater risk of multi-comorbidity.
本研究旨在通过纵向设计和跨诊断视角，评估临床结局、炎症活动、氧化和血管损伤以及代谢机制在检测合并精神疾病和肥胖症的个体进行体育活动训练后最大心率显著改善方面的预测效度和鉴别能力。
将患有重度抑郁症、双相情感障碍和精神分裂症且合并肥胖症的患者（n = 29）分配到一个为期12周的结构化体育锻炼项目中。在干预前后两次评估炎症、氧化应激、血管机制和代谢活动的外周血生物标志物，以及神经认知和功能表现。将最大心率视为体育活动有效性的标志物。进行了混合单因素方差分析和线性回归分析。
合并精神疾病和肥胖症的个体在体育活动训练后认知、情绪症状和体重指数有所改善，抗炎活性增加，同时氧化和心血管机制增强（p<0.05至0.0001；d = 0.47至1.63）。更好的临床结局以及炎症、氧化和心血管机制的调节对于预测随时间变化的显著最大心率变化至关重要（χ2 = 32.2至39.0，p < 0.0001）。
抗炎机制的调节对于跨精神疾病和肥胖症维持健康的体育活动可能至关重要。同样，炎症活动、氧化应激、血管和心脏代谢机制可能有助于识别具有多重合并症高风险的个体。
