Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan.
Department of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Eur Arch Psychiatry Clin Neurosci. 2023 Sep;273(6):1255-1265. doi: 10.1007/s00406-022-01530-5. Epub 2022 Dec 17.
Dysfunction in circulating endothelial progenitor cells (cEPCs) plays a crucial role in cardiovascular disorders (CVDs). Patients with bipolar disorder (BPD) are at increased risk of developing CVDs. This study examined the associations of the functional properties of cEPCs with BPD and its clinical and cognitive characteristics. We recruited 69 patients with BPD and 41 healthy controls (HCs). The levels of manic, depressive, anxiety, psychosomatic symptoms, subjective cognitive dysfunction, quality of life, and functional disability of the BPD group were evaluated using the Young Mania Rating Scale (YMRS), Clinical Global Impression for BPD (CGI-BP), Hamilton Depression Rating Scale, Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, Depression and Somatic Symptoms Scale, Perceived Deficits Questionnaire-Depression, 12-Item Short-Form Health Survey, and Sheehan Disability Scale, respectively. Cognitive function was assessed using 2-back and Go/No-Go tasks. Through in vitro assays, the adhesion to fibronectin and the percentage of apoptosis of cEPCs were examined. Under correction for multiple comparisons, the adhesive function of cEPCs in BPD was significantly lower than that in the HCs (corrected P [Pcorr] = 0.027). The reduced adhesive function of cEPCs correlated significantly with increased scores in the YMRS (Pcorr = 0.0002) and the CGI-BP (Pcorr = 0.0009). A lower percentage of apoptotic cEPC cells was associated with greater commission errors in the 2-back (Pcorr = 0.028) and Go/No-Go tasks (Pcorr = 0.029). The cEPCs of the BPD group exhibited attenuated adhesive function. The altered adhesive and apoptotic functions of cEPCs are associated with manic symptom severity and response inhibition deficits in patients with BPD.
循环内皮祖细胞 (cEPC) 功能障碍在心血管疾病 (CVD) 中起着至关重要的作用。双相障碍 (BPD) 患者发生 CVD 的风险增加。本研究探讨了 cEPC 功能特性与 BPD 及其临床和认知特征的相关性。我们招募了 69 名 BPD 患者和 41 名健康对照者 (HCs)。使用 Young Mania Rating Scale (YMRS)、Clinical Global Impression for BPD (CGI-BP)、Hamilton Depression Rating Scale、Montgomery-Åsberg Depression Rating Scale、Hamilton Anxiety Rating Scale、Depression and Somatic Symptoms Scale、Perceived Deficits Questionnaire-Depression、12-Item Short-Form Health Survey 和 Sheehan Disability Scale 分别评估 BPD 组的躁狂、抑郁、焦虑、身心症状、主观认知功能障碍、生活质量和功能障碍程度。使用 2 次回朔和 Go/No-Go 任务评估认知功能。通过体外检测，观察 cEPC 对纤维连接蛋白的黏附作用和凋亡比例。在多重比较校正后，BPD 患者的 cEPC 黏附功能明显低于 HCs (校正 P 值 [Pcorr] = 0.027)。cEPC 黏附功能的降低与 YMRS (Pcorr = 0.0002) 和 CGI-BP (Pcorr = 0.0009) 评分的增加显著相关。凋亡 cEPC 细胞的比例较低与 2 次回朔 (Pcorr = 0.028) 和 Go/No-Go 任务 (Pcorr = 0.029) 中的错误数较多相关。BPD 组的 cEPC 表现出黏附功能减弱。cEPC 的改变的黏附和凋亡功能与 BPD 患者的躁狂症状严重程度和反应抑制缺陷相关。
