分子手术刀剖析抗N-甲基-D-天冬氨酸受体脑炎中新的GluN1热点。
Molecular scalpels dissect new GluN1 hot spots in anti-NMDA receptor encephalitis.
作者信息
Spatola Marianna, Dalmau Josep
机构信息
IDIBAPS Biomedical Research Institute, Barcelona, Spain.
CaixaResearch Institute, Barcelona, Spain.
出版信息
Sci Immunol. 2025 Jan 3;10(103):eadv4913. doi: 10.1126/sciimmunol.adv4913.
PMID:39752539
Abstract
Patient-derived NMDAR mAbs combined with single-particle cryo-electron microscopy reveal multiple GluN1 epitopes and distinct functional effects.
摘要
患者来源的NMDAR单克隆抗体与单颗粒冷冻电子显微镜相结合揭示了多个GluN1表位和不同的功能效应。
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