胶质母细胞瘤中浆细胞与癌症干细胞的相互作用
Plasma cell and cancer stem cell crosstalk in glioblastoma.
作者信息
Kirschstein Elijah, Gunderson Andrew J
机构信息
Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.
Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Department of Surgery, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Cancer Cell. 2025 Jan 13;43(1):10-12. doi: 10.1016/j.ccell.2024.12.007. Epub 2025 Jan 2.
Plasma cells (PCs) are the main producers of antibodies and have context-dependent roles in tumor immunity. In this issue of Cancer Cell, Gao et al. report that intratumoral PCs drive maintenance of glioblastoma stem cells to promote tumor growth via IgG secretion that activates a FcγRIIA-SYK-AKT signaling axis.
浆细胞（PCs）是抗体的主要产生者，在肿瘤免疫中具有依赖于环境的作用。在本期《癌细胞》杂志中，高等人报道肿瘤内的浆细胞通过分泌激活FcγRIIA-SYK-AKT信号轴的IgG来驱动胶质母细胞瘤干细胞的维持，从而促进肿瘤生长。
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