[与受辐照肝癌细胞核基质相关的DNA位点上非计划合成的起始]
[Initiation of unscheduled synthesis on DNA sites associated with a nuclear matrix of irradiated hepatoma cells].
作者信息
Gaziev A I, Bezlepkin V G, Malinovskiĭ Iu Iu, Vel'chovsi V
出版信息
Radiobiologiia. 1985 Jan-Feb;25(1):137-8.
PMID:3975369
Abstract
A study was made of the distribution of unscheduled DNA synthesis (induced by UV- or gamma-radiation and resistant to hydroxyurea) between the DNA sites in the nuclear matrix and total nuclear DNA of Zajdela ascites hepatoma cells. It was shown that during the first 1.5 to 5 min of the postirradiation incubation the rate of the unscheduled synthesis of DNA was considerably higher in the DNA fraction, firmly associated with the nuclear matrix proteins, than in the total nuclear DNA.
摘要
对Zajdela腹水肝癌细胞核基质中的DNA位点与总核DNA之间的非预定DNA合成（由紫外线或γ辐射诱导并对羟基脲有抗性）分布进行了研究。结果表明，在辐射后孵育的最初1.5至5分钟内，与核基质蛋白紧密结合的DNA部分中DNA的非预定合成速率明显高于总核DNA中的合成速率。
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