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[与受辐照肝癌细胞核基质相关的DNA位点上非计划合成的起始]

[Initiation of unscheduled synthesis on DNA sites associated with a nuclear matrix of irradiated hepatoma cells].

作者信息

Gaziev A I, Bezlepkin V G, Malinovskiĭ Iu Iu, Vel'chovsi V

出版信息

Radiobiologiia. 1985 Jan-Feb;25(1):137-8.

PMID:3975369
Abstract

A study was made of the distribution of unscheduled DNA synthesis (induced by UV- or gamma-radiation and resistant to hydroxyurea) between the DNA sites in the nuclear matrix and total nuclear DNA of Zajdela ascites hepatoma cells. It was shown that during the first 1.5 to 5 min of the postirradiation incubation the rate of the unscheduled synthesis of DNA was considerably higher in the DNA fraction, firmly associated with the nuclear matrix proteins, than in the total nuclear DNA.

摘要

对Zajdela腹水肝癌细胞核基质中的DNA位点与总核DNA之间的非预定DNA合成(由紫外线或γ辐射诱导并对羟基脲有抗性)分布进行了研究。结果表明,在辐射后孵育的最初1.5至5分钟内,与核基质蛋白紧密结合的DNA部分中DNA的非预定合成速率明显高于总核DNA中的合成速率。

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1
[Initiation of unscheduled synthesis on DNA sites associated with a nuclear matrix of irradiated hepatoma cells].[与受辐照肝癌细胞核基质相关的DNA位点上非计划合成的起始]
Radiobiologiia. 1985 Jan-Feb;25(1):137-8.
2
[Change in the initiation of DNA synthesis on the nuclear matrix and its DNA-protein composition in gamma-irradiated hepatoma cells].
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[Preferential initiation of unscheduled DNA synthesis on areas associated with the nuclear matrix].[在与核基质相关区域优先启动非预定DNA合成]
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[Relation of the poly(ADP-ribosylation) of proteins to the formation and repair of DNA single-strand breaks in gamma-irradiated permeable Zajdela hepatoma cells].
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[The effect of proteinase inhibitors on the level of degradation and unscheduled synthesis of DNA in ultraviolet- and gamma-irradiated cellsof mouse ascitic carcinoma].[蛋白酶抑制剂对紫外线和γ射线照射的小鼠腹水癌细胞中DNA降解水平和非程序性合成的影响]
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Nuclear matrix proteins are crosslinked to transcriptionally active gene sequences by ionizing radiation.
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[Sensitivity of DNA synthesis to gamma-irradiation in Ehrlich ascites carcinoma cells in stationary and logarithmic growth phases].[艾氏腹水癌细胞静止期和对数生长期DNA合成对γ射线照射的敏感性]
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Chronic radiation-induced alteration in hematopoietic repair during preclinical phases of aplastic anemia and myeloproliferative disease: assessing unscheduled DNA synthesis responses.再生障碍性贫血和骨髓增殖性疾病临床前阶段造血修复中慢性辐射诱导的改变:评估非计划DNA合成反应。
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[Reorganization of the protein composition of the nuclear matrix of hepatoma cells after inhibition of DNA synthesis with novobiocin].
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