Huang Yuan-Zhe, Luo Fang, Ran Xiong, Yang Jian, Gu Min, Zhou Shao-Quan
Department of Radiology, Chongqing General Hospital, Chongqing University, Yubei District, Chongqing, 401147, China.
Department of Gastroenterology, Chongqing Traditional Chinese Medicine Hospital, Chongqing Academy of Traditional Chinese Medicine, Chongqing, 400021, China.
Sci Rep. 2025 Jan 3;15(1):630. doi: 10.1038/s41598-024-84597-5.
Heavy alcohol consumption is a known risk factor for type 2 diabetes (T2D), However, the moderating effect of fasting plasma glucose (FPG) levels remains unclear. This study explores the relationship between alcohol intake and T2D risk across FPG strata in a Japanese cohort. Data from 15,453 participants in the NAGALA cohort were analyzed over 5.4 years. Baseline assessments included alcohol consumption and FPG, categorizing individuals into elevated FPG (EFPG, 100-125 mg/dL) and normal FPG (NFPG, < 100 mg/dL). Cox proportional hazards regression assessed alcohol intake levels and T2D risk, stratified by FPG. Among EFPG individuals, heavy drinkers (Men > 280 g/week, Women > 140 g/week) had an 88% increased T2D risk (HR 1.88, 95% CI 1.24-2.84). Conversely, in NFPG, heavy alcohol intake did not significantly affect T2D risk (HR 1.10, 95% CI 0.48-2.53). Men with EFPG and heavy alcohol intake had an HR of 1.83 (95% CI 1.08-3.08), supported by propensity score matching (HR 1.94, 95% CI 1.13-3.34). No significant relationships were found in NFPG. Heavy alcohol consumption significantly raises T2D risk in Japanese men with EFPG but not in women or those with NFPG. Further studies are warranted for validation and gender-specific insights.
大量饮酒是2型糖尿病（T2D）的一个已知风险因素。然而，空腹血糖（FPG）水平的调节作用仍不清楚。本研究探讨了日本队列中不同FPG分层下酒精摄入量与T2D风险之间的关系。对NAGALA队列中15453名参与者的数据进行了5.4年的分析。基线评估包括酒精摄入量和FPG，将个体分为FPG升高（EFPG，100 - 125mg/dL）和FPG正常（NFPG，<100mg/dL）。Cox比例风险回归评估了按FPG分层的酒精摄入量水平和T2D风险。在EFPG个体中，重度饮酒者（男性>280g/周，女性>140g/周）患T2D的风险增加了88%（HR 1.88，95%CI 1.24 - 2.84）。相反，在NFPG个体中，大量饮酒对T2D风险没有显著影响（HR 1.10，95%CI 0.48 - 2.53）。EFPG且大量饮酒的男性HR为1.83（95%CI 1.08 - 3.08），倾向得分匹配支持这一结果（HR 1.94，95%CI 1.13 - 3.34）。在NFPG个体中未发现显著关系。大量饮酒显著增加了EFPG日本男性患T2D的风险，但在女性或NFPG个体中未增加。有必要进行进一步研究以进行验证并获得性别特异性见解。
