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[氨乙基异硫脲对受辐照小鼠免疫反应和干扰素生成的刺激作用]

[Stimulating effect of aminoethylisothiuronium on the immune response and interferonogenesis in irradiated mice].

作者信息

Zheleznikova G F, Ogurtsov R P, Stepanov A N

出版信息

Radiobiologiia. 1985 Jan-Feb;25(1):95-9.

PMID:3975380
Abstract

Aminoethylisothiuronium (AET) stimulated the formation of antibodies against sheep erythrocytes, not against E. coli, in X-irradiated (4 Gy) mice. The serum containing AET-induced interferon had the same effect. AET also promoted the rejection of the allogenic skin graft in mice irradiated with the same dose. In addition, AET and cystaphos stimulated the induction of interferon by the Newcastle disease virus in mice exposed to doses of 4, 5 or 6 Gy.

摘要

氨基乙基异硫脲(AET)能刺激经X射线照射(4戈瑞)的小鼠产生抗绵羊红细胞的抗体,而非抗大肠杆菌的抗体。含有AET诱导产生的干扰素的血清也有同样的效果。AET还能促进相同剂量照射的小鼠排斥同种异体皮肤移植。此外,AET和胱胺磷能刺激经4、5或6戈瑞剂量照射的小鼠被新城疫病毒诱导产生干扰素。

相似文献

1
[Stimulating effect of aminoethylisothiuronium on the immune response and interferonogenesis in irradiated mice].[氨乙基异硫脲对受辐照小鼠免疫反应和干扰素生成的刺激作用]
Radiobiologiia. 1985 Jan-Feb;25(1):95-9.
2
[Stimulation of antibody formation in irradiated animals with endogenous and exogenous interferon].[用内源性和外源性干扰素刺激受辐照动物的抗体形成]
Radiobiologiia. 1982 Jan-Feb;22(1):123-6.
3
Influence of a radioprotective substance AET-BrHBr (aminoethylisothiuronium-BrHBr) upon the survival half-time of erythrocytes labeled with 51 Cr in whole-body X-irradiated rats.放射防护物质AET - BrHBr(氨基乙基异硫脲 - BrHBr)对全身X线照射大鼠体内用51Cr标记的红细胞存活半衰期的影响。
Strahlentherapie. 1971 Jul;142(1):88-92.
4
[Immune response in mice exposed to low-dose X-rays].[暴露于低剂量X射线的小鼠的免疫反应]
C R Seances Soc Biol Fil. 1989;183(6):555-63.
5
[Comparative data on preventive effect of cysteamine (mercaptoethylamine) and AET (S-2-aminoethylisothiuronium dihydrobromide) against "intestinal radiation death"].
Orv Hetil. 1966 Jul 3;107(27):1257-61.
6
[The effect of S-2-aminoethylisothiuronium (AET) on the course of the pathological process and incidence of tumors in irradiated ovaries].[S-2-氨基乙基异硫脲(AET)对受照射卵巢病理过程进展及肿瘤发生率的影响]
Med Radiol (Mosk). 1968 Apr;13(4):42-5.
7
Colony-forming units and survival of irradiated mice treated with AET or endotoxin.
Radiat Res. 1969 Oct;40(1):149-76.
8
[Biochemical changes in the serum of non-irradiated and irradiated dogs following i.v. administration of AET].[静脉注射AET后未受照射和受照射犬血清中的生化变化]
Cas Lek Cesk. 1969 Nov;108(49):1470-8.
9
[The effect of S-2-aminoethylisothiuronium on the development of sclerotic changes in the kidneys of irradiated animals].[S-2-氨基乙基异硫脲对受辐照动物肾脏硬化性变化发展的影响]
Med Radiol (Mosk). 1969 Feb;14(2):31-5.
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[Effect of certain radiation-protective agents on sensitivity of irradiated animals to bacterial endotoxin].
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