Hamper U M, Khouri N F, Stitik F P, Siegelman S S
Radiology. 1985 Apr;155(1):15-8. doi: 10.1148/radiology.155.1.3975394.
Hamartomas of the lung often present as asymptomatic, noncharacteristic masses that can seldom be differentiated from other lung masses such as primary cancer or metastases by conventional radiography. Transthoracic needle-aspiration biopsy (TNAB) has become a popular and reliable method for the diagnosis of a lung lesion, and it offers a valuable alternative to diagnostic thoracotomy. In our study, TNAB established the diagnosis of pulmonary hamartoma in 12 of 14 (86%) patients. In eight patients, one procedure (using one to three punctures) was sufficient to establish the diagnosis, and, in four patients, two procedures (using one to two punctures) were necessary. In two patients, the lesion was missed on second and/or third biopsy procedures, and the correct diagnosis was obtained at surgery. Cytologic examination of the material was diagnostic in five of the 14 patients. Tissue specimens were sent in 13/14 patients, and findings of histologic examination established the correct diagnosis in 11 of these patients. One of the 12 patients in whom hamartoma was correctly diagnosed by TNAB underwent resection of his lesion, and histologic examination confirmed the diagnosis. In the remaining 11 patients, the lesions have been stable on follow-up chest examinations.
肺错构瘤通常表现为无症状的、无特征性的肿块，通过传统的X线摄影很少能与其他肺部肿块（如原发性癌症或转移瘤）区分开来。经胸针吸活检（TNAB）已成为诊断肺部病变的一种常用且可靠的方法，它为诊断性开胸手术提供了一种有价值的替代方法。在我们的研究中，TNAB在14例患者中的12例（86%）中确诊为肺错构瘤。在8例患者中，一次操作（穿刺一至三次）就足以确诊；在4例患者中，则需要两次操作（穿刺一至两次）。在2例患者中，第二次和/或第三次活检未发现病变，手术时才获得正确诊断。14例患者中有5例通过对取材进行细胞学检查得以确诊。14例患者中有13例送检了组织标本，其中11例经组织学检查结果确诊。12例经TNAB正确诊断为错构瘤的患者中有1例接受了病变切除，组织学检查证实了诊断。在其余11例患者中，后续胸部检查显示病变稳定。
