Kołcz Kinga, Reich Adam, Żychowska Magdalena
Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.
The Doctoral School, University of Rzeszow, Rzeszow, Poland.
Dermatol Ther (Heidelb). 2025 Feb;15(2):269-289. doi: 10.1007/s13555-024-01335-5. Epub 2025 Jan 3.
Ultraviolet-induced fluorescence dermoscopy (UVFD) is increasingly utilized in dermatooncology and general dermatology. The objective of the study was to characterize the ultraviolet-induced fluorescence trichoscopy (UVFT) findings in a wide range of hair and scalp conditions.
Consecutive patients with non-scarring alopecias (alopecia areata, AA, n = 40; androgenetic alopecia, AGA, n = 40), scarring alopecias (frontal fibrosing alopecia, FFA, n = 20; lichen planopilaris, LPP, n = 20; folliculitis decalvans, FD, n = 14; discoid lupus erythematosus, DLE, n = 23), and inflammatory scalp conditions (psoriasis, n = 30; seborrheic dermatitis, n = 14) were included. Examinations were performed using polarized trichoscopy and UVFT.
The following features were observed under UVFT: white-blue perifollicular fluorescence, white-blue interfollicular fluorescence, irregular confluent dark areas, dark follicular dots, dark perifollicular areas, regular/irregular pink-red follicular fluorescence, regular/irregular green follicular fluorescence, short white hair, black dots, exclamation mark hair, double/triple white follicular dots, pink-red fluorescence of the scales, pink-red fluorescence of the background. Non-scarring alopecias showed more frequently pink-red or green follicular fluorescence (p < 0.001), dark follicular dots (p < 0.001), short white hair (p < 0.001), and double/triple white follicular dots (p < 0.001). In scarring alopecias, white-blue perifollicular fluorescence (p < 0.001), dark perifollicular areas (p < 0.001), and dark confluent areas (p < 0.001) were more commonly observed. Psoriasis showed more frequently pink-red fluorescence of the scales than seborrheic dermatitis (p = 0.019).
UVFT supports the differentiation between scarring and non-scarring alopecia, as well as between psoriasis and seborrheic dermatitis. UVFT may hypothetically facilitate the biopsy site selection by highlighting the subclinical perifollicular and interfollicular inflammation.
紫外线诱导荧光皮肤镜检查（UVFD）在皮肤肿瘤学和普通皮肤科中的应用越来越广泛。本研究的目的是描述紫外线诱导荧光毛发镜检查（UVFT）在多种毛发和头皮疾病中的表现。
纳入了连续性的非瘢痕性脱发患者（斑秃，AA，n = 40；雄激素性脱发，AGA，n = 40）、瘢痕性脱发患者（额部纤维性脱发，FFA，n = 20；扁平苔藓样毛发苔藓，LPP，n = 20；脱发性毛囊炎，FD，n = 14；盘状红斑狼疮，DLE，n = 23）以及头皮炎症性疾病患者（银屑病，n = 30；脂溢性皮炎，n = 14）。使用偏振毛发镜和UVFT进行检查。
在UVFT下观察到以下特征：毛囊周围白蓝色荧光、毛囊间白蓝色荧光、不规则融合暗区、暗毛囊点、毛囊周围暗区、规则/不规则粉红色毛囊荧光、规则/不规则绿色毛囊荧光、白色短发、黑点、惊叹号样毛发、双/三白色毛囊点、鳞屑的粉红色荧光、背景的粉红色荧光。非瘢痕性脱发更常出现粉红色或绿色毛囊荧光（p < 0.001）、暗毛囊点（p < 0.001）、白色短发（p < 0.001）和双/三白色毛囊点（p < 0.001）。在瘢痕性脱发中，更常观察到毛囊周围白蓝色荧光（p < 0.001）、毛囊周围暗区（p < 0.001）和融合暗区（p < 0.001）。银屑病鳞屑的粉红色荧光比脂溢性皮炎更常见（p = 0.019）。
UVFT有助于区分瘢痕性和非瘢痕性脱发，以及银屑病和脂溢性皮炎。理论上，UVFT可能通过突出亚临床毛囊周围和毛囊间炎症来促进活检部位的选择。
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