Bittar Mohamad
Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, USA.
Curr Rheumatol Rep. 2025 Jan 4;27(1):11. doi: 10.1007/s11926-024-01178-1.
The purpose of this review is to highlight high impact clinical research in axial spondyloarthritis that was published between May 2023 and April 2024. These publications were presented at the SPARTAN annual meeting in May 2024.
Three publications addressed the rate and predictors of radiographic progression in axial spondyloarthritis. MRI-based synthetic CT was introduced as a new modality to assess spinal structural damage. One of the first definitions of difficult to treat axial spondyloarthritis was published. Biologic taper, flare rates, and predictors of flares were discussed. Minimally invasive one-level osteotomy can be an option to correct kyphosis with less risk compared to standard approach. Different therapeutic classes seem to be protective against anterior uveitis in axial spondyloarthritis. Patients who receive biologic or targeted synthetic disease modifying antirheumatic drugs are at increased risk of non-serious infections, but not serious infections that are associated with hospitalization or mortality. This year-in-review session covered different concepts, including imaging and radiographic progression, difficult to treat axial spondyloarthritis, biologic taper, surgery, anterior uveitis, and risk of infections.
本综述旨在突出2023年5月至2024年4月间发表的关于中轴型脊柱关节炎的高影响力临床研究。这些出版物在2024年5月的SPARTAN年会上展示。
三篇出版物探讨了中轴型脊柱关节炎的影像学进展率及预测因素。基于MRI的合成CT作为一种评估脊柱结构损伤的新方法被引入。难治性中轴型脊柱关节炎的首批定义之一已发表。讨论了生物制剂减量、复发率及复发的预测因素。与标准方法相比,微创单节段截骨术可作为一种风险较低的矫正后凸畸形的选择。不同治疗类别似乎对中轴型脊柱关节炎的前葡萄膜炎有保护作用。接受生物制剂或靶向合成改善病情抗风湿药物治疗的患者非严重感染风险增加,但与住院或死亡相关的严重感染风险未增加。本年度综述涵盖了不同概念,包括影像学和影像学进展、难治性中轴型脊柱关节炎、生物制剂减量、手术、前葡萄膜炎及感染风险。