Wang Yue, Lou Xiaoli, Yang Liyuan, Hou Yanqiang
Department of Clinical Laboratory, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Curr Pharm Des. 2025;31(16):1247-1258. doi: 10.2174/0113816128347060241105032329.
Chitosan is a kind of natural material with many unique physicochemical and biological properties related to antibacterial, antioxidant, and chelating. In recent years, chitosan-based nano gels (CS-NG) have been widely used in the field of cancer nanomedicine due to their excellent characteristics including biodegradability, biocompatibility, flexibility, large surface area, controllability, high loading capacity, and especially it can be engineered to become stimuli-responsive to tumor environments. In this review, we summarized the main synthesis approaches of CS-NGs including radical polymerization, self-assembly, microemulsion, and ionic gelation methods. These novel CS-NGs are applied in cancer nanomedicine serving as drug delivery, gene delivery, and bioimaging. Besides, we proposed our perspectives regarding the clinical development of CS-NGs cancer nanomedicine applications.
壳聚糖是一种天然材料，具有许多与抗菌、抗氧化和螯合相关的独特物理化学和生物学特性。近年来，基于壳聚糖的纳米凝胶（CS-NG）因其优异的特性，如生物可降解性、生物相容性、柔韧性、大表面积、可控性、高负载能力，尤其是可以设计成对肿瘤环境具有刺激响应性，已在癌症纳米医学领域得到广泛应用。在这篇综述中，我们总结了CS-NG的主要合成方法，包括自由基聚合、自组装、微乳液和离子凝胶化方法。这些新型CS-NG在癌症纳米医学中用作药物递送、基因递送和生物成像。此外，我们对CS-NG癌症纳米医学应用的临床开发提出了自己的观点。
