冲动强迫行为与左旋多巴诱发的运动障碍有关吗？一项巴西横断面研究。
Are impulsive compulsive behaviors associated with levodopa-induced dyskinesia? A Brazilian cross-sectional study.
作者信息
Veiga Beatriz A Anjos G, da Silva Carolina Candeias, Saba Roberta Arb, Silva Sonia Maria C A, Ferraz Henrique Ballalai, Borges Vanderci
机构信息
Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, Brazil.
Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, Brazil.
出版信息
Clin Neurol Neurosurg. 2025 Feb;249:108708. doi: 10.1016/j.clineuro.2024.108708. Epub 2024 Dec 28.
PURPOSE OF THIS RESEARCH
To study the association between ICBs and LIDs and to assess the predictors of ICBs in this sample.
METHODS
We intentionally evaluated 90 Brazilian PD patients younger than 60 in one evaluation that included the application of Questionnaire for Impulsive Compulsive Disorders - Current Short (QUIP-CS), Barratt Impulsive Scale-11 (BIS-11), Beck Depression Inventory-II (BDI-II), Unified Parkinson's Disease Rating Scale parts III and IV, Unified Dyskinesia Rating Scale (UDysRS), and a cognitive assessment.
RESULTS
ICB group had a longer PD duration (8.8 ± 5.2 y vs. 6.3 ± 3.3 y, p = 0.01), higher LEDDs (852.1 ± 381.8 mg vs.669.8 ± 404.4 mg, p = 0.03), higher BIS-11 scores (64.3 ± 12.7 vs. 58.6 ± 9.7, p = 0.01) and higher historical off-dystonia sub-scores (3.9 ± 5.0 vs. 2.0 ± 4.0, p = 0,05). LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk in both logistic models performed. MCI did not relate to ICBs.
CONCLUSION
In this study, LIDs did not increase ICB risk, older PD onset decreased, and impulsivity previous to PD increased ICB risk.
本研究目的
研究冲动控制障碍（ICBs）与左旋多巴诱导的异动症（LIDs）之间的关联，并评估该样本中ICBs的预测因素。
方法
我们对90名年龄小于60岁的巴西帕金森病患者进行了一次评估，评估内容包括应用冲动控制障碍问卷-当前简版（QUIP-CS）、巴拉特冲动量表-11（BIS-11）、贝克抑郁量表第二版（BDI-II）、统一帕金森病评定量表第三部分和第四部分、统一异动症评定量表（UDysRS）以及认知评估。
结果
ICB组帕金森病病程更长（8.8±5.2年 vs. 6.3±3.3年，p = 0.01），左旋多巴等效剂量更高（852.1±381.8毫克 vs. 669.8±404.4毫克，p = 0.03），BIS-11得分更高（64.3±12.7 vs. 58.6±9.7，p = 0.01），既往异动症亚评分更高（3.9±5.0 vs. 2.0±4.0，p = 0.05）。在进行的两个逻辑模型中，LIDs均未增加ICB风险，帕金森病发病年龄较大则风险降低，帕金森病之前的冲动性增加ICB风险。轻度认知障碍与ICBs无关。
结论
在本研究中，LIDs未增加ICB风险，帕金森病发病年龄较大则风险降低，帕金森病之前的冲动性增加ICB风险。
Zotero 插件