Kong Chee Hoe, Steffi Chris, Cai Yanli, Wang Wilson
Department of Orthopaedic Surgery, National University of Singapore, NUHS Tower Block, Level 11, 1E Kent Ridge Road, Singapore 119228, Singapore.
Institut für Biomechanik, ETH Zürich, GLC H 20.2, Gloriastrasse 37/39, 8092 Zürich, Switzerland.
Biomater Adv. 2025 Apr;169:214173. doi: 10.1016/j.bioadv.2024.214173. Epub 2025 Jan 2.
Osteoporosis, characterized by reduced bone mineral density and increased fracture risk, poses a significant health challenge, particularly for aging populations. Systemic treatments often lead to adverse side effects, emphasizing the need for localized solutions. This study introduces a 3D-printed polycaprolactone (PCL) scaffold embedded with strontium-substituted mesoporous bioactive glass nanoparticles (Sr-MBGNPs) and icariin (ICN) for the targeted regeneration of osteoporotic bone. The scaffold was characterized using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), ion release studies, and cellular assays, which confirmed its dual functionality in both enhancing osteoblast proliferation and differentiation and inhibiting osteoclastogenesis. The optimized Sr-MBGNP concentration ensured sustained ion release, superior hydrophilicity, and bioactivity without compromising scaffold integrity. Additionally, e-jet printing provided high precision and uniform pore sizes conducive to cellular activity. This novel scaffold platform demonstrates a promising localized treatment strategy, reducing systemic side effects while improving fixation stability. The innovative integration of Sr-MBGNPs and ICN highlights its potential to revolutionize osteoporosis therapy by promoting bone regeneration and mitigating bone resorption.
骨质疏松症以骨矿物质密度降低和骨折风险增加为特征，对健康构成重大挑战，尤其是对老年人群体。全身治疗往往会导致不良副作用，这凸显了局部治疗方案的必要性。本研究介绍了一种3D打印的聚己内酯（PCL）支架，该支架嵌入了锶取代的介孔生物活性玻璃纳米颗粒（Sr-MBGNPs）和淫羊藿苷（ICN），用于骨质疏松性骨的靶向再生。使用扫描电子显微镜（SEM）、能量色散光谱（EDS）、离子释放研究和细胞试验对该支架进行了表征，证实了其在促进成骨细胞增殖和分化以及抑制破骨细胞生成方面的双重功能。优化后的Sr-MBGNP浓度确保了离子的持续释放、优异的亲水性和生物活性，同时不影响支架的完整性。此外，电子喷射打印提供了高精度和均匀的孔径，有利于细胞活性。这种新型支架平台展示了一种有前景的局部治疗策略，在提高固定稳定性的同时减少全身副作用。Sr-MBGNPs和ICN的创新性整合突出了其通过促进骨再生和减轻骨吸收来彻底改变骨质疏松症治疗的潜力。
