Bridi Michelle C D, Peixoto Lucia
Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26505, USA.
Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine, Washington State University Spokane, 99202, USA.
Curr Opin Neurobiol. 2025 Feb;90:102968. doi: 10.1016/j.conb.2024.102968. Epub 2025 Jan 3.
Sleep problems occur more frequently in individuals with autism spectrum disorder (ASD) than in typically developing individuals, and recent studies support a genetic link between ASD and sleep disturbances. However, it remains unclear how sleep problems may be mechanistically connected to ASD phenotypes. A longstanding hypothesis posits that an imbalance between excitatory and inhibitory (E/I) signaling in the brain underlies the behavioral characteristics of ASD. In recent years, emerging evidence has shown that regulation of the E/I ratio is coupled to sleep/wake states in wild-type animal models. In this review, we will explore the idea of altered E/I regulation over the sleep/wake cycle as a mechanism bridging sleep disruption and behavioral phenotypes in ASD.
自闭症谱系障碍（ASD）患者比正常发育的个体更容易出现睡眠问题，最近的研究支持ASD与睡眠障碍之间存在遗传联系。然而，睡眠问题与ASD表型之间的机制联系仍不清楚。一个长期存在的假说是，大脑中兴奋性和抑制性（E/I）信号之间的失衡是ASD行为特征的基础。近年来，新出现的证据表明，在野生型动物模型中，E/I比值的调节与睡眠/觉醒状态相关联。在这篇综述中，我们将探讨在睡眠/觉醒周期中E/I调节改变这一观点，它是连接ASD睡眠中断和行为表型的一种机制。
