拼凑脑钙化机制以促进治疗进展。（原英文表述似乎有误，正确可能是“Piecing together...” ，但按照给定内容翻译如上）

P-ecing together brain calcification mechanisms for therapeutic advancement.

作者信息

Bekkelund Åse K, Siggervåg Anette, Aksnes Henriette

机构信息

Department of Biomedicine, University of Bergen, Bergen, Norway.

出版信息

Trends Mol Med. 2025 Mar;31(3):206-208. doi: 10.1016/j.molmed.2024.12.003. Epub 2025 Jan 4.

DOI:10.1016/j.molmed.2024.12.003

PMID:39755442

Abstract

Seven primary familial brain calcification genes have been identified but their role in disease mechanisms has been less explored. Cheng et al. recently demonstrated that astrocyte-mediated regulation of brain phosphate (P) involves direct and functional interactions among three of these proteins, paving the way for new strategies to combat brain calcification.

摘要

已经确定了七个原发性家族性脑钙化基因，但它们在疾病机制中的作用尚未得到充分探索。Cheng等人最近证明，星形胶质细胞介导的脑磷酸盐（P）调节涉及其中三种蛋白质之间的直接和功能性相互作用，为对抗脑钙化的新策略铺平了道路。