一种促进脂滴形成的新机制。
A novel mechanism promoting lipid droplet formation.
作者信息
Yang Zheng, Zhang Meng, Du Chang
机构信息
Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Science, South China Normal University, Guangzhou 510631, China; Zhengzhou Research Base, National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, China.
College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, China.
出版信息
Trends Plant Sci. 2025 Apr;30(4):347-349. doi: 10.1016/j.tplants.2024.12.010. Epub 2025 Jan 3.
Recently, Torres-Romero et al. identified a novel lipid droplet (LD)-associated protein, α/β-hydrolase domain containing protein 1 (ABHD1), in algae. Structurally, ABHD1 promotes the budding and growth of LDs and, functionally, it hydrolyzes lyso-diacylglyceryl-N,N,N-trimethylhomoserine (lyso-DGTS) to generate glyceryl-N,N,N-trimethylhomoserine (GTS) and free fatty acids (FFAs). Taken together, ABHD1 mediates a novel pathway for LD formation.
最近，托雷斯 - 罗梅罗等人在藻类中鉴定出一种新的与脂滴（LD）相关的蛋白质，即含α/β水解酶结构域蛋白1（ABHD1）。在结构上，ABHD1促进脂滴的出芽和生长，在功能上，它水解溶血二酰基甘油 - N，N，N - 三甲基高丝氨酸（溶血 - DGTS）以生成甘油 - N，N，N - 三甲基高丝氨酸（GTS）和游离脂肪酸（FFA）。综上所述，ABHD1介导了一种新的脂滴形成途径。
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