Al-Thnaibat Mohammad Hassan, Urabi Heba M, Alkofahi Hadeel S, Alshriedeh Ola Mohannad, Alshraideh Raneem, Esmadi Hanan, Sheyyab Ahmed, Roumi Jamal Bakri, Hasan Hanan Khaled
Hashemite University, Zarqa, Jordan.
Jordan University of Science and Technology, Irbid, Jordan.
BMC Nephrol. 2025 Jan 4;26(1):6. doi: 10.1186/s12882-024-03922-2.
Patients with end-stage renal disease usually undergo hemodialysis as a way of renal function replacement therapy which comes with a wide array of systemic and cutaneous complications. The aim of this study was to evaluate the most frequent dermatological manifestations including xerosis, pruritis and other nail, hair and oral conditions, as these are a very important aspect to be considered while managing the patients psychological and physical needs to improve their outcomes and quality of life.
This retrospective cross-sectional study was performed by selecting 77 patients on hemodialysis based on a certain criteria and data was then collected on a sheet using patients database on Hakeem National E-Health Program, in addition to information from interviews with patients during their hemodialysis sessions after taking an oral informed consent and insuring patients' privacy. Data was analyzed using IBM SPSS Statistics for Windows, Version 20.0.
83.1% (N = 64) of the participants on hemodialysis presented with one or multiple skin conditions. Generalized xerosis, generalized pruritis, pigmentary alterations and arteriovenous (AV) shunt-associated complications were found in 63.6% (N = 49), 36.4% (N = 28), 16.9% (N = 13) and 7.8% (N = 6) respectively. Terry's nails (19.5%, N = 15) were also a common nail abnormality along with other nail disorders (18.2%, N = 14). Different oral anomalies were associated with 14.3% (N = 11) of subjects and in 22.1% (N = 17), diffuse scalp hair loss was also identified.
Cutaneous issues such as xerosis, pruritus, pigmentary changes, and nail abnormalities are prevalent among ESRD patients, reflecting the broader systemic effects of chronic kidney disease. Our findings underscore the urgency of early recognition, comprehensive evaluation, and tailored management strategies to improve the physical and psychological burden on patients. Moving forward, targeted research into the underlying mechanisms and innovative therapeutic approaches is essential to enhance both dermatological outcomes and overall patient well-being.
终末期肾病患者通常接受血液透析作为肾功能替代治疗的一种方式，这会带来一系列全身和皮肤并发症。本研究的目的是评估最常见的皮肤表现，包括皮肤干燥、瘙痒以及其他指甲、毛发和口腔问题，因为在满足患者心理和生理需求以改善其治疗效果和生活质量的过程中，这些是需要考虑的非常重要的方面。
本回顾性横断面研究通过根据特定标准选择77例接受血液透析的患者进行，然后使用哈基姆国家电子健康计划中的患者数据库在一张表格上收集数据，此外，在获得口头知情同意并确保患者隐私后，通过与患者在血液透析期间的访谈收集信息。使用IBM SPSS Statistics for Windows 20.0版对数据进行分析。
83.1%（N = 64）的血液透析参与者出现一种或多种皮肤问题。全身性皮肤干燥、全身性瘙痒、色素改变和动静脉（AV）分流相关并发症分别见于63.6%（N = 49）、36.4%（N = 28）、16.9%（N = 13）和7.8%（N = 6）的患者。泰瑞氏指甲（19.5%，N = 15）以及其他指甲疾病（18.2%，N = 14）也是常见的指甲异常。14.3%（N = 11）的受试者存在不同的口腔异常，22.1%（N = 17）的受试者还出现弥漫性头皮脱发。
皮肤干燥、瘙痒、色素变化和指甲异常等皮肤问题在终末期肾病患者中很普遍，反映了慢性肾病更广泛的全身影响。我们的研究结果强调了早期识别、综合评估和量身定制管理策略以减轻患者身心负担的紧迫性。展望未来，针对潜在机制和创新治疗方法的靶向研究对于改善皮肤治疗效果和患者整体健康至关重要。
