Zhang Yihui, Shi Yuan, Zhang Ye, Jiao Jian, Tang Xiangdong
Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
Sleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, China.
Brain Res Bull. 2025 Feb;221:111190. doi: 10.1016/j.brainresbull.2025.111190. Epub 2025 Jan 3.
Sleep deprivation is a common public problem, and researchers speculated its neurophysiological mechanisms related to cortical excitatory and inhibitory activity. Recently, transcranial magnetic stimulation combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) have been used to assess cortical excitability in sleep-deprived individuals, but the results were inconsistent. Therefore, we conducted a meta-analysis to summarize relevant TMS-evoked indices of excitability and inhibition for exploring the cortical effects of sleep deprivation. In TMS-EMG studies, short-interval cortical inhibition (SICI) significantly decreased in sleep-deprived subjects; while the intracortical facilitation (ICF), resting motor threshold (RMT), and cortical silent period (CSP) were not significant compared to healthy controls. In TMS-EEG studies, the amplitude and slope of TMS-evoked potential (TEP) increased in sleep-deprived subjects. This study indicated that cortical inhibition decreased following sleep deprivation based on the TMS-EMG results and cortical excitability enhanced in the TMS-EEG results, supporting the disturbance of cortical excitability in sleep-deprived individuals.
睡眠剥夺是一个常见的公共问题，研究人员推测其神经生理机制与皮层兴奋性和抑制性活动有关。最近，经颅磁刺激结合肌电图（TMS-EMG）和脑电图（TMS-EEG）已被用于评估睡眠剥夺个体的皮层兴奋性，但结果并不一致。因此，我们进行了一项荟萃分析，以总结相关的TMS诱发的兴奋性和抑制性指标，以探索睡眠剥夺对皮层的影响。在TMS-EMG研究中，睡眠剥夺受试者的短间隔皮层抑制（SICI）显著降低；而与健康对照组相比，皮层内易化（ICF）、静息运动阈值（RMT）和皮层静息期（CSP）无显著差异。在TMS-EEG研究中，睡眠剥夺受试者的TMS诱发电位（TEP）的幅度和斜率增加。这项研究表明，根据TMS-EMG结果，睡眠剥夺后皮层抑制降低，而根据TMS-EEG结果，皮层兴奋性增强，这支持了睡眠剥夺个体皮层兴奋性的紊乱。
