CK2依赖性SK通道功能障碍是阿尔茨海默病神经元兴奋性过高的一个因素。

CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer's disease.

作者信息

Wei Xiaojie, Sun Binggui

机构信息

Department of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou, Zhejiang Province 310058, China; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province 310020, China.

Department of Anesthesiology of the Children's Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang University, Hangzhou, Zhejiang Province 310058, China; NHC and CAMS Key Laboratory of Medical Neurobiology, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China.

出版信息

Trends Neurosci. 2025 Feb;48(2):98-99. doi: 10.1016/j.tins.2024.12.006. Epub 2025 Jan 4.

DOI:10.1016/j.tins.2024.12.006

PMID:39757072

Abstract

Neuronal hyperexcitability in the cortex and hippocampus represents an early event in Alzheimer's disease (AD). In a recent study, Blankenship and colleagues reported that in a mouse of AD, ventral tegmental area (VTA) dopamine neurons are also hyperexcitable, and this hyperexcitability is due to casein kinase 2 (CK2)-dependent SK channel dysfunction, adding new insights into the underlying mechanisms of aberrant neuronal properties in AD.

摘要

大脑皮层和海马体中的神经元过度兴奋是阿尔茨海默病（AD）的早期事件。在最近的一项研究中，布兰肯希普及其同事报告称，在AD小鼠中，腹侧被盖区（VTA）多巴胺能神经元也存在过度兴奋，且这种过度兴奋是由酪蛋白激酶2（CK2）依赖性SK通道功能障碍所致，这为AD中异常神经元特性的潜在机制提供了新见解。