Scher K S, Baldera A, Wheeler W E, Walker R, Jones C W
South Med J. 1985 Feb;78(2):153-6. doi: 10.1097/00007611-198502000-00008.
Three cases of tetanus occurring in a community in southern West Virginia in five years prompted a survey of the immunization status of the population of this region. An immunization history was obtained from 540 consecutive patients seen at three different health care facilities. Of these, 386 (71.5%) had received prior tetanus protection, 65 (12%) had never been immunized, and 89 (16.5%) were uncertain or had received incomplete immunization. Of the 65 nonimmunized patients, 54 (83%) were older than 50 and only 11 (17%) were younger. Compared to the total group sampled, significantly more nonimmunized patients (both male and female) were older than 50 (P less than .001). Also, significantly more of these never immunized individuals lived in rural areas (P less than .001). In a group of 222 patients identified as being at increased risk of having tetanus, 65 (29%) had never been immunized, 89 (40%) were of uncertain or incomplete status, and 68 (30.5%) had been immunized more than ten years previously. One hundred twenty (54%) high-risk patients were older than 50 and 103 (46%) were younger. Compared to the entire population sampled, high-risk patients included significantly more who were older than 50 (P less than .001). Also, significantly more high-risk patients lived in rural areas (P less than .007). When treating injured patients, it is important to recall that many older adults living in rural areas are not adequately immunized against tetanus. Such patients should receive human tetanus immunoglobulin, as well as tetanus toxoid.
西弗吉尼亚州南部一个社区在五年内出现了三例破伤风病例,这促使人们对该地区人口的免疫状况进行调查。从三家不同医疗保健机构连续接诊的540名患者那里获取了免疫史。其中,386人(71.5%)曾接受过破伤风预防,65人(12%)从未接种过疫苗,89人(16.5%)情况不明或接种不完全。在65名未接种疫苗的患者中,54人(83%)年龄在50岁以上,只有11人(17%)年龄在50岁以下。与抽样总体相比,未接种疫苗的患者(包括男性和女性)年龄在50岁以上的比例显著更高(P小于0.001)。此外,这些从未接种疫苗的人中居住在农村地区的比例也显著更高(P小于0.001)。在一组被确定为破伤风风险增加的222名患者中,65人(29%)从未接种过疫苗,89人(40%)情况不明或接种不完全,68人(30.5%)在十年多以前接种过疫苗。120名(54%)高危患者年龄在50岁以上,103名(46%)年龄在50岁以下。与整个抽样人群相比,高危患者中年龄在50岁以上的比例显著更高(P小于0.001)。此外,居住在农村地区的高危患者比例也显著更高(P小于0.007)。在治疗受伤患者时,必须记住,许多居住在农村地区的老年人破伤风免疫不足。这类患者应接受破伤风人免疫球蛋白以及破伤风类毒素。