Raza Ishaq Ali, A S El-Nashar Heba, M Al-Qaaneh Ayman, Bashir Aneela, Younis Tahira
State Key Laboratory of Biocatalysis and Enzyme Engineering, Environmental Microbial Technology Center of Hubei, College of Life Science, Hubei University, Wuhan, China.
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Egypt.
Nat Prod Res. 2025 Jan 5:1-23. doi: 10.1080/14786419.2024.2436119.
Orientin is one of the flavonoid glycosides with diverse biological properties such as anticancer, antioxidant, neuroprotective, cardioprotective, antiallergic, and anti-inflammatory. It is found in several plants like rooibos tea, , , , and species. This review aimed to summarise the various medicinal properties of the orientin focusing on its underlying molecular mechanism reported based on and studies. The data were collected using various search engines, incorporating PubMed/Medline, Scopus, Science Direct, Google Scholar, Web of Science, and SpringerLink. Our findings showed that orientin exhibited promising anticancer, neuroprotective, anti-inflammatory, and antioxidant activities. Hopefully, this information could assist drug researchers and pharmaceutical entities in finding an effective herbal drug for the treatment of different disorders with potential mechanisms of action. Meanwhile, further investigations are warranted such as oral bioavailability, pharmacokinetics and pharmacodynamic characteristics of orientin to establish fully drug profiling suitable for clinical trials.
荭草苷是一种黄酮苷类化合物，具有多种生物学特性，如抗癌、抗氧化、神经保护、心脏保护、抗过敏和抗炎等。它存在于多种植物中，如南非红叶茶等。本综述旨在总结荭草苷的各种药用特性，重点关注基于体内和体外研究报道的其潜在分子机制。数据通过各种搜索引擎收集，包括PubMed/Medline、Scopus、Science Direct、谷歌学术、科学网和SpringerLink。我们的研究结果表明，荭草苷具有良好的抗癌、神经保护、抗炎和抗氧化活性。希望这些信息能够帮助药物研究人员和制药企业找到一种有效的草药药物，用于治疗具有潜在作用机制的不同疾病。同时，有必要进一步研究荭草苷的口服生物利用度、药代动力学和药效学特征，以建立适合临床试验的完整药物概况。
