Newbill E T, Johns M E, Cantrell R W
South Med J. 1985 Mar;78(3):275-82.
Esthesioneuroblastoma is an uncommon nasal tumor originating from cells of neural crest origin. An increased awareness of this neoplasm by clinicians and pathologists has led to an increase in its diagnosis. In the Department of Otolaryngology--Head and Neck Surgery at the University of Virginia Medical Center, 22 cases have been treated. A review of the biologic course of these cases has allowed us to make certain recommendations for therapy. Patients with stage A and B disease are best treated with preoperative radiation therapy followed by craniofacial resection. Patients with stage C disease are treated with cyclophosphamide and vincristine before irradiation and craniofacial resection. If a significant response occurs these patients receive postoperative chemotherapy. We believe this treatment should result in five-year survivals in excess of 50%.
嗅神经母细胞瘤是一种罕见的鼻腔肿瘤，起源于神经嵴来源的细胞。临床医生和病理学家对这种肿瘤的认识提高，导致其诊断率上升。在弗吉尼亚大学医学中心耳鼻咽喉头颈外科，已治疗了22例。对这些病例生物学病程的回顾使我们能够对治疗提出某些建议。A期和B期疾病的患者最好先进行术前放射治疗，然后进行颅面切除术。C期疾病的患者在放疗和颅面切除术前用环磷酰胺和长春新碱治疗。如果出现显著反应，这些患者接受术后化疗。我们相信这种治疗应能使五年生存率超过50%。
