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变革癌症治疗:揭示CAR-T细胞疗法的力量。

Revolutionizing Cancer Treatment: Unveiling the Power of CAR T-cell Therapy.

作者信息

Barjasteh Amir Hossein, Saebi Mostafa, Mahmoudi Mahmoud, Kheder Ramiar Kamal, Hashemy Seyed Isaac, Forouzanfar Fatemeh, Esmaeili Seyed-Alireza

机构信息

Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Curr Pharm Des. 2025;31(13):1020-1036. doi: 10.2174/0113816128336391241107112957.

Abstract

Cancer is a significant health challenge worldwide, causing social and economic burdens. Despite advancements in medicine, it remains a leading cause of death and is projected to increase by 2040. While conventional treatments like surgery, radiation, and chemotherapy are effective, they often have severe side effects. CAR T-cell (chimeric antigen receptor T-cell) treatment is a novel immunotherapy method personalized to the patient's immune system and directly targets cancer cells. It originated in the 1980s, and advancements have made it more effective. However, challenges remain, such as severe side effects, high costs, and manufacturing variability. Despite these challenges, the treatment with CAR T-cells has shown remarkable success, especially in hematologic malignancies. Though, it is new to solid tumours, ongoing research looks promising. CAR T-cell therapy offers hope for fightingcancer, and it stands poised to redefine cancer treatment paradigms, giving renewed optimism to patients globally.

摘要

癌症是全球一项重大的健康挑战,会造成社会和经济负担。尽管医学取得了进步,但它仍是主要的死亡原因,预计到2040年还会增加。虽然手术、放疗和化疗等传统治疗方法有效,但它们往往有严重的副作用。嵌合抗原受体T细胞(CAR T细胞)治疗是一种针对患者免疫系统的新型免疫疗法,直接靶向癌细胞。它起源于20世纪80年代,并且技术进步使其更加有效。然而,挑战依然存在,比如严重的副作用、高昂的成本和生产变异性。尽管有这些挑战,CAR T细胞治疗已显示出显著成效,尤其是在血液系统恶性肿瘤方面。不过,对于实体瘤来说它还是新方法,正在进行的研究看起来很有前景。CAR T细胞疗法为抗击癌症带来了希望,它有望重新定义癌症治疗模式,给全球患者带来新的乐观情绪。

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