Stuhec Matej, Gazdag Anteja Gorjan, Cuk Zala, Oravecz Robert, Batinic Borjanka
Medical Faculty Maribor, Department of Pharmacology, University of Maribor, Maribor, Slovenia.
Department of Clinical Pharmacy, Ormoz's Psychiatric Hospital, Ormoz, Slovenia.
Front Psychiatry. 2024 Dec 20;15:1473832. doi: 10.3389/fpsyt.2024.1473832. eCollection 2024.
One potential strategy to address inadequate screening for somatic comorbidities among patients with mental disorders is to integrate a clinical pharmacist into the inpatient team for daily interdisciplinary ward rounds. This approach remains under-researched in psychiatric hospitals. This study aimed to evaluate the impact of a clinical pharmacist on drug-related problems (DRPs) during daily ward rounds within an interdisciplinary team in a psychiatric hospital.
A retrospective observational pre-post study was conducted at the Ormož Psychiatric Hospital in Slovenia, including patients treated between 2019 and 2020, during which clinical pharmacists offered recommendations during daily ward rounds. The primary outcomes assessed the difference in the total number of DRPs observed at the time of hospital discharge compared to previous stage, as well as the recommendations and their continuation rate after three months. The secondary outcomes evaluated adherence to treatment guidelines.
The study included 186 patients (mean age: 58.1 years, SD=17.0). During ward rounds, 280 recommendations related to DRPs were conducted (1.5 recommendations per patient). Regarding the nature of DRPs, 154 (55.0%) were identified as expressed DRPs, while 127 (45.0%) were deemed potential DRPs. Following pharmacist recommendations, 133 (86.4%) of the expressed DRPs were successfully resolved. The majority of DRPs pertained to treatment effectiveness (N=179, 63.9%), followed by unnecessary treatments (N=86, 30.7%) and patient safety (N=15, 5.4%). Initially, the acceptance rate of recommendations was 88.9% (N=249) at discharge, declining to 63.2% (N=177) three months after discharge. The acceptance rate for somatic conditions at discharge was 87.8% (N=122), declining to 59.0% (N=82) three months after discharge. Adherence to treatment guidelines for somatic comorbidities increased (p < 0.05).
The results indicate that this approach led to fewer DRPs, a high rate of acceptance, and better adherence to treatment guidelines. This is the first retrospective pre-post study in the European Union to include this collaboration in daily rounds at psychiatric hospitals, focusing on somatic comorbidities. However, the study also has significant limitations, such as its non-randomized design and short monitoring period, which should be addressed in future research.
解决精神障碍患者躯体合并症筛查不足的一种潜在策略是将临床药师纳入住院团队进行每日跨学科病房查房。这种方法在精神病医院的研究仍较少。本研究旨在评估临床药师在精神病医院跨学科团队每日病房查房期间对药物相关问题(DRP)的影响。
在斯洛文尼亚的奥尔莫日精神病医院进行了一项回顾性观察前后对照研究,纳入2019年至2020年期间接受治疗的患者,在此期间临床药师在每日病房查房时提供建议。主要结局评估出院时观察到的DRP总数与前一阶段相比的差异,以及建议及其三个月后的持续率。次要结局评估对治疗指南的依从性。
该研究纳入了186名患者(平均年龄:58.1岁,标准差=17.0)。在病房查房期间,共提出了280条与DRP相关的建议(每位患者1.5条建议)。关于DRP的性质,154条(55.0%)被确定为已表达的DRP,而127条(45.0%)被视为潜在的DRP。根据药师的建议,133条(86.4%)已表达的DRP得到成功解决。大多数DRP与治疗效果有关(N=179,63.9%),其次是不必要的治疗(N=86,30.7%)和患者安全(N=15,5.4%)。最初,出院时建议的接受率为88.9%(N=249),出院三个月后降至63.2%(N=177)。出院时躯体疾病的接受率为87.8%(N=122),出院三个月后降至59.0%(N=82)。对躯体合并症治疗指南的依从性有所提高(p<0.05)。
结果表明,这种方法导致DRP减少、接受率高且对治疗指南的依从性更好。这是欧盟第一项回顾性前后对照研究,将这种合作纳入精神病医院的每日查房,重点关注躯体合并症。然而,该研究也有显著局限性,如非随机设计和监测期短,未来研究应加以解决。