Saxena Parnika P, Turnbull Adam, Kim Daniel, Sommer Barbara, Vankee Lin F
Department of Psychiatry and Behavioral Sciences, Stanford University, USA.
Aging Brain. 2024 Oct 14;6:100126. doi: 10.1016/j.nbas.2024.100126. eCollection 2024.
Affective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understand and treat. The distressing nature of these symptoms and complexity of their concurrence and interaction necessitates improved understanding of their underlying neural correlates. We analyzed the relationships between functional brain topology (i.e., the way the brain's functional network is organized to allow efficient communication between regions) and affective symptoms in aMCI using cross-sectional and longitudinal methods. The analyses demonstrated that increased clustering coefficient (CC) was related to lower baseline and greater decreases in affective symptoms, while higher participation coefficient (PC) was correlated with more severe baseline affective symptoms. These findings suggest that the brain losing the capacity to form segregated functional units may be related to prevalence and severity of affective symptoms seen in aMCI.
情感症状（即抑郁、焦虑和冷漠）是临床前痴呆（如遗忘型轻度认知障碍，aMCI）中神经精神症状（NPS）最常见的亚综合征，并且在理解和治疗方面仍然是一个挑战。这些症状令人痛苦的性质以及它们同时出现和相互作用的复杂性，需要我们更好地理解其潜在的神经关联。我们使用横断面和纵向方法分析了aMCI患者功能性脑拓扑结构（即大脑功能网络的组织方式，以实现区域间有效通信）与情感症状之间的关系。分析表明，聚类系数（CC）增加与较低的基线情感症状以及情感症状更大程度的减轻相关，而参与系数（PC）较高则与更严重的基线情感症状相关。这些发现表明，大脑失去形成隔离功能单元的能力可能与aMCI中情感症状的发生率和严重程度有关。
