Kang Min Ho, Kim So Hee, Park Jae Hoon, Yeom Suh Hee, Park Jung Eun, Kim Jin Woo
Department of Food Science, Sun Moon University, 70, Sunmoon-ro 221 Beon-Gil, Tangjeong-Myeon, Asansi, Chungcheongnam-do Korea.
Center for Next-Generation Semiconductor Technology, Sun Moon University, 70 Sunmoon-ro 221, Tangjeong-Myeon, Asan-si, 336-708 Chungnam Korea.
Food Sci Biotechnol. 2024 Sep 11;34(1):227-236. doi: 10.1007/s10068-024-01654-5. eCollection 2025 Jan.
Chronic inflammation is persistent disease caused by unregulated activation of pathway and production of pro-inflammatory cytokines, induced by accumulation of reactive oxygen species above thresholds. The purpose of this study was to evaluate the anti-oxidant, anti-lipidemia, inhibition pathway, and reduction of pro-inflammatory cytokine activities of extract (IDE) to demonstrate its inhibitory ability against chronic inflammatory in RAW264.7. Polyphenol content, radical scavenging activity, and lipase activity inhibition of IDE were 9.2 ± 0.2 GAE mg/g dry matter, 84.7%, and 72.4%, respectively, showing high effects against anti-oxidant and lipolysis inhibitory. Furthermore, anti-inflammatory effects of IDE on LPS-induced RAW 264.7 were investigated, and expression of inflammatory genes such as , , , , , and were decreased by 36.5%-83.4%. Studies have confirmed that IDE has excellent antioxidant, lipolysis inhibitory, and anti-inflammatory effects, and can be used as natural ingredients for food and medicine to prevent.
慢性炎症是由信号通路的失控激活和促炎细胞因子的产生所导致的持续性疾病，其由活性氧物种积累超过阈值所诱导。本研究的目的是评估 提取物（IDE）的抗氧化、抗血脂、抑制信号通路以及降低促炎细胞因子活性的能力，以证明其对RAW264.7细胞中慢性炎症的抑制能力。IDE的多酚含量、自由基清除活性和脂肪酶活性抑制率分别为9.2±0.2 GAE mg/g干物质、84.7%和72.4%，显示出对抗氧化和脂肪分解抑制的高效性。此外，研究了IDE对脂多糖诱导的RAW 264.7细胞的抗炎作用，并且 、 、 、 、 和 等炎症基因的表达下降了36.5%-83.4%。研究证实，IDE具有出色的抗氧化、脂肪分解抑制和抗炎作用，并且可作为食品和药物的天然成分用于预防。 （注：原文中部分基因名称未完整给出，翻译时保留原文形式）
