Egan Kia Kejlskov, Pisinger Veronica, Becker Ulrik, Tolstrup Janne Schurmann
National Institute of Public Health, University of Southern Denmark, DK-1455 Copenhagen, Denmark.
Addict Behav Rep. 2024 Dec 5;21:100576. doi: 10.1016/j.abrep.2024.100576. eCollection 2025 Jun.
Individuals with problematic alcohol use often face anxiety and depressive symptoms, which can hinder treatment engagement, compliance, and effectiveness. Psychosocial therapy through video conference (e-alcohol therapy) may reduce these barriers. We explored whether 1) anxiety or/and depressive symptoms modify the effect of proactive e-alcohol therapy on treatment initiation, compliance, and alcohol intake, 2) proactive e-alcohol therapy impacts anxiety or/and depressive symptoms compared to standard care.
Participants with problematic alcohol use were recruited online and randomly assigned to proactive e-alcohol therapy or standard care. Problematic alcohol use was defined by an 8+ score on the Alcohol Use Disorders Identification Test. Anxiety and depressive symptoms were measured using the Patient Health Questionnaire-4.
356 individuals participated; 133 showed moderate-severe symptoms of anxiety and depression at baseline. There were no significant differences between individuals with and without moderate-severe anxiety or/and depressive symptoms in the effect of proactive e-alcohol therapy versus standard care on treatment initiation (3 mo: p = 0.64; 12 mo: p = 0.97), compliance (3 mo: p = 0.40; 12 mo: p = 0.58), or alcohol intake (3 mo: p = 0.86; 12 mo: p = 0.90). No significant differences were found in the proportion of participants with moderate-severe anxiety and depressive symptoms between the two intervention groups after 3 months (OR 0.6; 95 % CI 0.3 to 1.4; p = 0.27).
We found no evidence that anxiety or/and depressive symptoms modify the effect of proactive e-alcohol therapy on treatment initiation, compliance, or alcohol intake. Proactive e-alcohol therapy matched standard care in reducing anxiety or/and depressive symptoms over a 3-month follow-up.
有酒精使用问题的个体常面临焦虑和抑郁症状，这可能会妨碍治疗参与度、依从性和疗效。通过视频会议进行的心理社会治疗（电子酒精治疗）可能会减少这些障碍。我们探讨了：1）焦虑或/和抑郁症状是否会改变积极电子酒精治疗对治疗启动、依从性和酒精摄入量的影响；2）与标准护理相比，积极电子酒精治疗是否会影响焦虑或/和抑郁症状。
通过网络招募有酒精使用问题的参与者，并将其随机分配到积极电子酒精治疗组或标准护理组。酒精使用问题通过酒精使用障碍识别测试中8分及以上的得分来定义。使用患者健康问卷-4来测量焦虑和抑郁症状。
356人参与；133人在基线时表现出中度至重度焦虑和抑郁症状。在治疗启动（3个月：p = 0.64；12个月：p = 0.97）、依从性（3个月：p = 0.40；12个月：p = 0.58）或酒精摄入量（3个月：p = 0.86；12个月：p = 0.90）方面，有或没有中度至重度焦虑或/和抑郁症状的个体在积极电子酒精治疗与标准护理的效果上没有显著差异。3个月后，两个干预组中中度至重度焦虑和抑郁症状参与者的比例没有显著差异（比值比0.6；95%置信区间0.3至1.4；p = 0.27）。
我们没有发现证据表明焦虑或/和抑郁症状会改变积极电子酒精治疗对治疗启动、依从性或酒精摄入量的影响。在为期3个月的随访中，积极电子酒精治疗在减轻焦虑或/和抑郁症状方面与标准护理相当。
