一种含有β-酮酯部分的开启型荧光探针，用于细胞内肼的选择性检测。
A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine.
作者信息
Takagi Akira, Takashima Ippei, Okuda Kensuke
机构信息
Laboratory of Bioorganic & Natural Products Chemistry, Kobe Pharmaceutical University 4-19-1, Motoyamakita, Higashinada Kobe Hyogo 658-8558 Japan
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University 2-1-1 Katahira, Aoba Sendai Miyagi 980-8577 Japan.
出版信息
RSC Adv. 2025 Jan 3;15(1):428-434. doi: 10.1039/d4ra06525e. eCollection 2025 Jan 2.
Fluorogenic probes containing the β-ketoester structure were developed for selective hydrazine detection. The probe equipped with a cyclopropane moiety, having reduced steric hindrance, showed a higher reaction rate than its dimethyl counterpart. In live cell imaging, the probe detects intracellular hydrazine with minimal cytotoxicity. This study introduces a promising tool for hydrazine detection that may assist in reducing the risks associated with hydrazine exposure in various applications.
开发了含有β-酮酯结构的荧光探针用于选择性肼检测。配备有环丙烷部分且空间位阻减小的探针，其反应速率比其二甲基对应物更高。在活细胞成像中，该探针能以最小的细胞毒性检测细胞内的肼。本研究介绍了一种有前景的肼检测工具，可有助于降低各种应用中与肼暴露相关的风险。
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