Nguyen Khac Hong, Hao Yuanqiang, Chen Wansong, Zhang Yintang, Xu Maotian, Yang Minghui, Liu You-Nian
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan Province, P. R. China.
Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan Province, P. R. China.
Luminescence. 2018 Aug;33(5):816-836. doi: 10.1002/bio.3505. Epub 2018 Jun 13.
Hydrazine (N H ) is an important and commonly used chemical reagent for the preparation of textile dyes, pharmaceuticals, pesticides and so on. Despite its widespread industrial applications, hydrazine is highly toxic and exposure to this chemical can cause many symptoms and severe damage to the liver, kidneys, and central nervous system. As a consequence, many efforts have been devoted to the development of fluorescent probes for the selective sensing and/or imaging of N H . Although great efforts have been devoted in this area, the large number of important recent studies have not yet been systematically discussed in a review format so far. In this review, we have summarized the recently reported fluorescent N H probes, which are classified into several categories on the basis of the recognition moieties. Moreover, the sensing mechanism and probes designing strategy are also comprehensively discussed on aspects of the unique chemical characteristics of N H and the structures and spectral properties of fluorophores.
肼（N₂H₄）是一种重要且常用的化学试剂，用于制备纺织染料、药品、农药等。尽管肼在工业上有广泛应用，但它具有高毒性，接触这种化学物质会引发多种症状，并对肝脏、肾脏和中枢神经系统造成严重损害。因此，人们致力于开发用于选择性传感和/或成像N₂H₄的荧光探针。尽管在这一领域已付出巨大努力，但大量近期的重要研究至今尚未以综述形式进行系统讨论。在本综述中，我们总结了最近报道的荧光N₂H₄探针，这些探针根据识别基团分为几类。此外，还基于N₂H₄的独特化学特性以及荧光团的结构和光谱特性，全面讨论了传感机制和探针设计策略。
