• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

激活的PRDM1-CREBBP通过调节人滋养层细胞的凋亡和侵袭促进子痫前期。

Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells.

作者信息

Zhang Xuan, Sun Lei

机构信息

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, P.R. China.

出版信息

iScience. 2024 Dec 3;27(12):111484. doi: 10.1016/j.isci.2024.111484. eCollection 2024 Dec 20.

DOI:10.1016/j.isci.2024.111484
PMID:39759022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11699622/
Abstract

Preeclampsia (PE) is a multifactorial disorder of pregnancy, characterized by new-onset gestational hypertension. High-throughput mRNA sequencing (RNA-seq) was performed to analyze the gene expression patterns in placentas from patients with early-onset PE (EOPE). PR domain zinc-finger protein 1 (PRDM1) expression increased in the chorionic villi and placental basal plate from patients with PE and nitro--arginine methyl ester (L-NAME)-treated rats. Inhibition of PRDM1 enhanced trophoblast/extravillous trophoblast (EVT) cell invasion/migration and reduced apoptosis under hypoxia/reoxygenation (H/R) conditions. RNA-seq data indicated that the expression of CREB-binding protein (CREBBP), a transcriptional coactivator, was upregulated in preeclamptic placentas and showed a positive correlation with that of PRDM1. Genetic and pharmacological inhibition of CREBBP exhibited anti-apoptotic and pro-invasive roles. H/R stimulation upregulated CREBBP expression and augmented the binding of PRDM1 to CREBBP's promoter. CREBBP was further validated as a direct downstream target of PRDM1. Collectively, our work reveals an involvement of the activated PRDM1-CREBBP axis in PE-associated trophoblast dysfunction.

摘要

子痫前期（PE）是一种妊娠多因素疾病，其特征为新发妊娠高血压。进行了高通量mRNA测序（RNA测序）以分析早发型子痫前期（EOPE）患者胎盘的基因表达模式。PE患者和用硝基 - 精氨酸甲酯（L - NAME）处理的大鼠的绒毛膜绒毛和胎盘基底板中PR结构域锌指蛋白1（PRDM1）表达增加。在缺氧/复氧（H/R）条件下，抑制PRDM1可增强滋养细胞/绒毛外滋养细胞（EVT）的侵袭/迁移并减少细胞凋亡。RNA测序数据表明，转录共激活因子CREB结合蛋白（CREBBP）在子痫前期胎盘中表达上调，并且与PRDM1的表达呈正相关。对CREBBP的基因和药理学抑制表现出抗凋亡和促侵袭作用。H/R刺激上调了CREBBP的表达，并增强了PRDM1与CREBBP启动子的结合。CREBBP被进一步验证为PRDM1的直接下游靶点。总体而言，我们的研究揭示了激活的PRDM1 - CREBBP轴参与了PE相关的滋养细胞功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/d22f8f5c1ba3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/7792c06318f8/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/be8f11d8f02a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/421e5c683d7b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/a46ee645950f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/45b421cf0551/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/33b129df5c6b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/36007bf6d692/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/d22f8f5c1ba3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/7792c06318f8/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/be8f11d8f02a/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/421e5c683d7b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/a46ee645950f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/45b421cf0551/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/33b129df5c6b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/36007bf6d692/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd98/11699622/d22f8f5c1ba3/gr7.jpg

相似文献

1
Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells.激活的PRDM1-CREBBP通过调节人滋养层细胞的凋亡和侵袭促进子痫前期。
iScience. 2024 Dec 3;27(12):111484. doi: 10.1016/j.isci.2024.111484. eCollection 2024 Dec 20.
2
Knockdown of activated Cdc42-associated kinase inhibits human extravillous trophoblast migration and invasion and decreases protein expression of pho-Akt and matrix metalloproteinase.敲低活化的Cdc42相关激酶可抑制人绒毛外滋养层细胞的迁移和侵袭，并降低磷酸化Akt和基质金属蛋白酶的蛋白表达。
J Matern Fetal Neonatal Med. 2020 Apr;33(7):1125-1133. doi: 10.1080/14767058.2018.1515196. Epub 2018 Oct 3.
3
Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker.子痫前期中蜕膜细胞的decorin 过表达：一种潜在的血液生物标志物。
Am J Obstet Gynecol. 2016 Sep;215(3):361.e1-361.e15. doi: 10.1016/j.ajog.2016.03.020. Epub 2016 Mar 19.
4
Cyclosporin A alleviates trophoblast apoptosis and senescence by promoting autophagy in preeclampsia.环孢素 A 通过促进子痫前期的自噬来减轻滋养细胞凋亡和衰老。
Placenta. 2022 Jan;117:95-108. doi: 10.1016/j.placenta.2021.11.003. Epub 2021 Nov 12.
5
Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta.胎盘基底板螺旋动脉生理性转化失败、内皮细胞和滋养层细胞激活以及急性动脉粥样硬化。
Am J Obstet Gynecol. 2017 Mar;216(3):287.e1-287.e16. doi: 10.1016/j.ajog.2016.12.029. Epub 2016 Dec 27.
6
ANXA4 promotes trophoblast invasion via the PI3K/Akt/eNOS pathway in preeclampsia.ANXA4 通过 PI3K/Akt/eNOS 通路促进子痫前期滋养细胞侵袭。
Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C481-C491. doi: 10.1152/ajpcell.00404.2018. Epub 2019 Jan 23.
7
Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas.层粘连蛋白α4（LAMA4）的表达促进滋养层细胞的侵袭、迁移和血管生成，且在子痫前期胎盘组织中表达降低。
Placenta. 2015 Aug;36(8):809-20. doi: 10.1016/j.placenta.2015.04.008. Epub 2015 May 21.
8
Inhibiting HNF4A suppresses inflammation whilst promoting trophoblast invasion and migration: A promising target for the treatment of preeclampsia.抑制肝细胞核因子4α可抑制炎症，同时促进滋养层细胞的侵袭和迁移：子痫前期治疗的一个有前景的靶点。
Chem Biol Interact. 2023 Dec 1;386:110752. doi: 10.1016/j.cbi.2023.110752. Epub 2023 Oct 6.
9
Dysregulated BMP2 in the Placenta May Contribute to Early-Onset Preeclampsia by Regulating Human Trophoblast Expression of Extracellular Matrix and Adhesion Molecules.胎盘内骨形态发生蛋白2（BMP2）失调可能通过调节人滋养层细胞细胞外基质和黏附分子的表达而导致早发型子痫前期。
Front Cell Dev Biol. 2021 Dec 14;9:768669. doi: 10.3389/fcell.2021.768669. eCollection 2021.
10
Decorin-induced, preeclampsia-associated microRNA-512-3p restrains extravillous trophoblast functions by targeting USF2/PPP3R1 axis.核心蛋白聚糖诱导的、与子痫前期相关的微小RNA-512-3p通过靶向USF2/PPP3R1轴抑制绒毛外滋养层细胞功能。
Front Cell Dev Biol. 2022 Oct 10;10:1014672. doi: 10.3389/fcell.2022.1014672. eCollection 2022.

本文引用的文献

1
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.PRDM1/BLIMP1 通过调节肝癌细胞中的 USP22-SPI1-PD-L1 轴诱导癌症免疫逃逸。
Nat Commun. 2022 Dec 12;13(1):7677. doi: 10.1038/s41467-022-35469-x.
2
Reliability of Rodent and Rabbit Models in Preeclampsia Research.啮齿动物和兔模型在子痫前期研究中的可靠性。
Int J Mol Sci. 2022 Nov 18;23(22):14344. doi: 10.3390/ijms232214344.
3
The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health.
先兆子痫的 L-NAME 小鼠模型及其对长期母体心血管健康的影响。
Life Sci Alliance. 2022 Aug 5;5(12):e202201517. doi: 10.26508/lsa.202201517.
4
Human leukocyte antigen HLA-C, HLA-G, HLA-F, and HLA-E placental profiles are altered in early severe preeclampsia and preterm birth with chorioamnionitis.人类白细胞抗原 HLA-C、HLA-G、HLA-F 和 HLA-E 的胎盘谱在早发性重度子痫前期和伴有绒毛膜羊膜炎的早产中发生改变。
Am J Obstet Gynecol. 2022 Oct;227(4):641.e1-641.e13. doi: 10.1016/j.ajog.2022.07.021. Epub 2022 Jul 19.
5
Primary Human Trophoblasts Mimic the Preeclampsia Phenotype after Acute Hypoxia-Reoxygenation Insult.原发性人滋养层细胞在急性低氧-复氧损伤后模拟子痫前期表型。
Cells. 2022 Jun 11;11(12):1898. doi: 10.3390/cells11121898.
6
PRDM1 Drives Human Primary T Cell Hyporesponsiveness by Altering the T Cell Transcriptome and Epigenome.PRDM1 通过改变 T 细胞转录组和表观基因组来驱动人类原代 T 细胞反应迟钝。
Front Immunol. 2022 Apr 28;13:879501. doi: 10.3389/fimmu.2022.879501. eCollection 2022.
7
Maternal exposure to CeONPs derails placental development through trophoblast dysfunction mediated by excessive autophagy activation.母体暴露于 CeONPs 通过过度自噬激活介导的滋养层功能障碍破坏胎盘发育。
J Nanobiotechnology. 2022 Mar 15;20(1):131. doi: 10.1186/s12951-022-01334-8.
8
Genetic ablation of PRDM1 in antitumor T cells enhances therapeutic efficacy of adoptive immunotherapy.抗肿瘤 T 细胞中 PRDM1 的基因缺失增强了过继免疫疗法的治疗效果。
Blood. 2022 Apr 7;139(14):2156-2172. doi: 10.1182/blood.2021012714.
9
Vascular Dysfunction in Preeclampsia.子痫前期中的血管功能障碍。
Cells. 2021 Nov 6;10(11):3055. doi: 10.3390/cells10113055.
10
Cell dynamics in human villous trophoblast.人类绒毛滋养层细胞动力学。
Hum Reprod Update. 2021 Aug 20;27(5):904-922. doi: 10.1093/humupd/dmab015.