Zhang Dongxing, Han Wei, Yang Yang, Tong Xin, Xiao Jing
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, 101199, People's Republic of China.
Institute of Urology, Beijing Municipal Health Commission, Beijing, 101199, People's Republic of China.
J Multidiscip Healthc. 2024 Dec 31;17:6255-6264. doi: 10.2147/JMDH.S496819. eCollection 2024.
Clinically, metabolic syndrome (MetS) is associated with the formation and relapse of kidney stones diseases (KSD). In the general population, dietary selenium can reduce renal damage by reducing oxidative stress and other physiological pathways. Less is known, however, about the association between dietary selenium and KSD in patients with MetS.
The present study's purpose is to evaluate the association between dietary selenium intake and the odds of KSD in MetS populations.
Data of MetS patients aged ≥20 years were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2007-2018). The information of dietary selenium intake was obtained by 24-hour dietary recall interview. Weighted univariable and multivariate logistic regression analyses were used to evaluate the association of selenium intake with KSD in MetS patients and described as odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analysis was performed to further discuss this association based on age, gender, and MetS component.
In total, 6,073 patients were included, with 766 (12.61%) KSD cases. After adjusting for covariates, high dietary selenium intake was related to lower odds of KSD in MetS patients (OR = 0.70, 95% CI = 0.50-0.97), especially in females (OR = 0.61, 95% CI = 0.39-0.96), those aged <65 years (OR = 0.53, 95% CI = 0.35-0.80), without a history of hypertriglyceridemia (OR = 0.61, 95% CI = 0.40-0.93) and with a history of hypertension (OR = 0.57, 95% CI = 0.38-0.84), diabetes (OR = 0.68, 95% CI = 0.46-0.99) or central obesity (OR = 0.67, 95% CI = 0.48-0.95).
From this cross-sectional study, we observed that, among patients with MetS, high dietary selenium intake is associated with lower odds of KSD, implying a potential nutritional strategy for preventing KSD in this population.
在临床上，代谢综合征（MetS）与肾结石疾病（KSD）的形成和复发相关。在普通人群中，膳食硒可通过减轻氧化应激及其他生理途径来减少肾脏损伤。然而，关于膳食硒与MetS患者KSD之间的关联，我们所知甚少。
本研究旨在评估膳食硒摄入量与MetS人群中KSD发生几率之间的关联。
从国家健康与营养检查调查（NHANES）数据库（2007 - 2018年）中提取年龄≥20岁的MetS患者数据。通过24小时膳食回顾访谈获取膳食硒摄入量信息。采用加权单变量和多变量逻辑回归分析来评估MetS患者中硒摄入量与KSD的关联，并以优势比（OR）和95%置信区间（CI）表示。基于年龄、性别和MetS组分进行亚组分析以进一步探讨这种关联。
总共纳入6073例患者，其中766例（12.61%）为KSD病例。在调整协变量后，高膳食硒摄入量与MetS患者较低的KSD发生几率相关（OR = 0.70，95% CI = 0.50 - 0.97），尤其是在女性中（OR = 0.61，95% CI = 0.39 - 0.96）、年龄<65岁的人群中（OR = 0.53，95% CI = 0.35 - 0.80）、无高甘油三酯血症病史者中（OR = 0.61，95% CI = 0.40 - 0.93）以及有高血压病史者中（OR = 0.57，95% CI = 0.38 - 0.84）、糖尿病病史者中（OR = 0.68，95% CI = 0.46 - 0.99）或中心性肥胖病史者中（OR = 0.67，95% CI = 0.48 - 0.95）。
通过这项横断面研究，我们观察到，在MetS患者中，高膳食硒摄入量与较低的KSD发生几率相关，这意味着在该人群中预防KSD的一种潜在营养策略。
