Huang Yulan, Gao Yuan, Lin Zhenghong, Miao Hongming
Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
School of Life Sciences, Chongqing University, Chongqing 401331, China.
Genes Dis. 2024 Feb 2;12(2):101240. doi: 10.1016/j.gendis.2024.101240. eCollection 2025 Mar.
The tumor microenvironment is a complex environment comprising tumor cells, non-tumor cells, and other critical non-cellular components. Some studies about tumor microenvironment have recently achieved remarkable progress in tumor treatment. As a substantial part of post-translational protein modification, ubiquitination is a crucial player in maintaining protein stability in cell signaling, cell growth, and a series of cellular life activities, which are also essential for regulating tumor cells or other non-tumor cells in the tumor microenvironment. This review focuses on the role and function of ubiquitination and deubiquitination modification in the tumor microenvironment while discussing the prospect of developing inhibitors targeting ubiquity-related enzymes, thereby providing ideas for future research in cancer therapy.
肿瘤微环境是一个复杂的环境，由肿瘤细胞、非肿瘤细胞和其他关键的非细胞成分组成。最近，一些关于肿瘤微环境的研究在肿瘤治疗方面取得了显著进展。作为蛋白质翻译后修饰的重要组成部分，泛素化在维持细胞信号传导、细胞生长和一系列细胞生命活动中的蛋白质稳定性方面起着关键作用，而这些对于调节肿瘤微环境中的肿瘤细胞或其他非肿瘤细胞也至关重要。本综述重点讨论泛素化和去泛素化修饰在肿瘤微环境中的作用和功能，同时探讨开发靶向泛素相关酶抑制剂的前景，从而为未来癌症治疗研究提供思路。
