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一名75岁有乳腺癌病史女性的煤工尘肺酷似肺癌:一例临床病例报告

Coal Worker's Pneumoconiosis Mimicking Lung Cancer in a 75-Year-Old Woman With a History of Breast Cancer: A Clinical Case Report.

作者信息

Pakbaz Yeganeh, Moodi Farzan

机构信息

School of Medicine Iran University of Medical Sciences Tehran Iran.

出版信息

Clin Case Rep. 2025 Jan 2;13(1):e70049. doi: 10.1002/ccr3.70049. eCollection 2025 Jan.

Abstract

Pneumoconiosis, caused by inhaling mineral dust, remains a significant occupational disease, despite a declining incidence. Coal workers' pneumoconiosis (CWP), a common subtype, varies in presentation from simple to complicated forms. Differential diagnosis is crucial, especially when CWP manifests as lung masses mimicking malignancy. We present a case of CWP in a 75-year-old female with a history of breast cancer, initially suspected of lung cancer due to an incidental mass on chest radiography. Clinical examination, laboratory tests, chest tomography, and biopsy were conducted. The patient, with a history of biomass fuel exposure, presented with a left upper lung mass, initially thought to be lung cancer. Biopsy-induced hemopneumothorax led to intensive care admission. Histopathology confirmed CWP and conservative management resulted in recovery. Imaging revealed a solid mass in the left upper lung with lymphadenopathy. Histopathology showed carbon-laden macrophages and anthracosis, consistent with CWP. Imaging modalities, including MRI and FDG-PET/CT, aid in differentiating CWP from cancer. CWP, mimicking lung cancer, underscores the importance of accurate diagnosis. Imaging features, including nodules with calcifications, guide diagnosis. MRI and FDG-PET/CT offer valuable insights, albeit with limitations, emphasizing the need for judicious use based on clinical suspicion.

摘要

尽管发病率呈下降趋势,但吸入矿物粉尘引起的尘肺病仍然是一种重要的职业病。煤工尘肺(CWP)是一种常见的亚型,其表现形式从简单到复杂各不相同。鉴别诊断至关重要,尤其是当CWP表现为类似恶性肿瘤的肺部肿块时。我们报告一例75岁患有乳腺癌病史的女性煤工尘肺病例,该患者最初因胸部X线检查偶然发现肿块而被怀疑患有肺癌。进行了临床检查、实验室检查、胸部断层扫描和活检。该患者有生物质燃料接触史,表现为左上肺肿块,最初被认为是肺癌。活检引起的血气胸导致其入住重症监护病房。组织病理学确诊为煤工尘肺,保守治疗后康复。影像学检查显示左上肺有实性肿块伴淋巴结肿大。组织病理学显示有含碳巨噬细胞和煤尘沉着症,符合煤工尘肺。包括MRI和FDG-PET/CT在内的影像学检查有助于鉴别煤工尘肺和癌症。类似肺癌表现的煤工尘肺凸显了准确诊断的重要性。包括有钙化结节在内的影像学特征有助于诊断。MRI和FDG-PET/CT虽有局限性,但能提供有价值的见解,强调需要根据临床怀疑谨慎使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b03/11695462/9a5c4b949e9f/CCR3-13-e70049-g001.jpg

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