In vitro effect of cadmium on primary antibody response to T-cell independent antigen (DNP-Ficoll).

The effect of various concentrations of cadmium on the in vitro primary antibody response to T-cell independent antigen (DNP-Ficoll) was investigated. Anti DNP-Ficoll antibody response in mice was significantly enhanced by 8 microM cadmium, but suppressed by 20 and 40 microM cadmium. However, cell viabilities were decreased by cadmium exposure with dose-dependent relationships. The results suggest that in vitro exposure to cadmium produces different effects on antibody responses.