Mitema E S, Maribei J M
Toxicol Lett. 1985 Jan;24(1):53-8. doi: 10.1016/0378-4274(85)90139-0.
Two groups of 6 rats each received subcutaneous injections of 2.3 mg/kg or 5.0 mg/kg of quinuronium, respectively, on two consecutive days, while 5 rats injected with physiological saline served as controls. Clinical signs of muscular tremors, jumps, enlarged and hyperemic eyeballs, lacrimation, depression and anorexia were observed following administration of quinuronium. One rat receiving 5 mg/kg died before termination of the study. When killed 48 h after the first injection, the quinuronium-treated rats had a higher liver weight/body weight ratio compared to the controls. Quinuronium resulted in hepatic centrilobular fatty degeneration, but no depletion of hepatic glutathione (GSH). The present findings suggest that glutathione depletion does not seem to be involved in quinuronium hepatotoxicity.
两组各6只大鼠连续两天分别皮下注射2.3毫克/千克或5.0毫克/千克的喹核铵，而5只注射生理盐水的大鼠作为对照。注射喹核铵后观察到肌肉震颤、跳跃、眼球肿大充血、流泪、抑郁和厌食等临床症状。一只接受5毫克/千克剂量的大鼠在研究结束前死亡。首次注射48小时后处死时，喹核铵处理组大鼠的肝脏重量/体重比高于对照组。喹核铵导致肝小叶中心性脂肪变性，但肝谷胱甘肽（GSH）未耗竭。目前的研究结果表明，谷胱甘肽耗竭似乎与喹核铵肝毒性无关。
