Bin Sumaida Abdulrahman, Shanbhag Nandan M, AlKaabi Khalifa, Hasnain Syed Mansoor, Balaraj Khalid
Oncology: Radiation Oncology, Tawam Hospital, Al Ain, ARE.
Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, ARE.
Cureus. 2024 Dec 6;16(12):e75222. doi: 10.7759/cureus.75222. eCollection 2024 Dec.
Background Adenoid cystic carcinoma (ACC) is a rare malignancy characterized by slow progression, local recurrence, and distant metastases. This study aims to evaluate the demographic patterns, clinical presentations, outcomes, and survival trends of patients with ACC. Methods A retrospective analysis of 14 patients diagnosed with ACC from 2010 to 2024 at a tertiary cancer center in the United Arab Emirates was conducted. Data on demographics, presenting symptoms, clinical outcomes, tumor characteristics, recurrence patterns, and survival were analyzed. Kaplan-Meier survival analysis was performed to evaluate survival trends. Results The cohort was predominantly male (64.3%, n=9) with a mean age of 38.9 years. An enlarging mass in the neck (50%, n=7) was the most common presenting symptom. Local recurrence and distant metastases were observed in 42.9% (n=6) of patients each, with the lungs being the most frequent site of metastases (83.3%, n=5). Advanced-stage disease (Stage III/IV) was common (64.3%, n=9). Overall survival was 85.7% (n=12) over a mean follow-up of 4.3 years. Smoking was associated with poorer survival trends, though not statistically significant (HR=7.0, p=0.083). Conclusion ACC predominantly affects middle-aged individuals and is associated with high rates of local recurrence and distant metastases, especially to the lungs. Although survival trends varied by gender, smoking, and metastases, these differences were not statistically significant, underscoring the need for larger studies to better elucidate prognostic factors.
腺样囊性癌（ACC）是一种罕见的恶性肿瘤，其特征为进展缓慢、局部复发和远处转移。本研究旨在评估ACC患者的人口统计学模式、临床表现、治疗结果和生存趋势。方法：对2010年至2024年在阿拉伯联合酋长国一家三级癌症中心确诊为ACC的14例患者进行回顾性分析。分析了人口统计学、症状表现、临床结果、肿瘤特征、复发模式和生存数据。采用Kaplan-Meier生存分析评估生存趋势。结果：该队列以男性为主（64.3%，n = 9），平均年龄38.9岁。颈部肿块增大（50%，n = 7）是最常见的症状表现。42.9%（n = 6）的患者出现局部复发和远处转移，肺是最常见的转移部位（83.3%，n = 5）。晚期疾病（III/IV期）常见（64.3%，n = 9）。平均随访4.3年，总生存率为85.7%（n = 12）。吸烟与较差的生存趋势相关，但无统计学意义（HR = 7.0，p = 0.083）。结论：ACC主要影响中年个体，且局部复发和远处转移率高，尤其是肺转移。尽管生存趋势因性别、吸烟和转移情况而异，但这些差异无统计学意义，这突出表明需要进行更大规模的研究以更好地阐明预后因素。
