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一例罕见的脊椎椎间盘炎。

A rare case of spondylodiscitis.

作者信息

Belote Alex, Hammoud Kassem

机构信息

Division of Infectious Diseases, Department of Medicine, University of Kansas, Kanas City, KS, USA.

出版信息

IDCases. 2024 Dec 12;39:e02126. doi: 10.1016/j.idcr.2024.e02126. eCollection 2025.

Abstract

A 55-year-old-male with a chronic left uretero-pelvic junction (UPJ) obstruction managed with intermittent stent exchanges presented with low midline back pain. CT Abdomen/Pelvis revealed spondylodiscitis at L4-L5, further demonstrated on MRI Lumbar spine. Imaging also revealed the left nephro-ureteral stent was mispositioned, with some mild wall thickening of the left ureter. He was not systemically ill, and antimicrobials were held. He underwent a L4/5 disc biopsy, and pathology revealed acute discitis. Blood and biopsy cultures remained negative through hospital day 5. He then underwent repeat L4/5 disc biopsy. Cultures of repeat biopsy resulted in . IV antimicrobials were stopped, and oral Metronidazole was started. He completed 10 weeks of Metronidazole therapy, with significant clinical improvement. is a rare cause of bone and joint infections. It is difficult to culture and is less virulent than common bacteria associated with native vertebral osteomyelitis. There have been few case reports of osteomyelitis or prosthetic joint infection, especially in males. can rarely colonize the urethra in men and has been known to form biofilm on foreign material in the female genitourinary system. We suspect our patient had developed colonization of his ureteral stent, predisposing him to osteomyelitis. Were repeat biopsy not pursued in this case, our patient likely could have developed empiric treatment failure. Holding antibiotics after initial biopsy proved highly beneficial.

摘要

一名55岁男性,因慢性左肾盂输尿管连接处(UPJ)梗阻接受间歇性支架置换治疗,出现中下腹疼痛。腹部/盆腔CT显示L4-L5椎体椎间盘炎,腰椎MRI进一步证实。影像学检查还显示左肾输尿管支架位置不当,左输尿管壁有轻度增厚。他没有全身感染症状,停用了抗菌药物。他接受了L4/5椎间盘活检,病理显示为急性椎间盘炎。至住院第5天,血液和活检培养结果均为阴性。随后他再次接受L4/5椎间盘活检。重复活检培养结果为……停用静脉抗菌药物,开始口服甲硝唑。他完成了10周的甲硝唑治疗,临床症状有显著改善。……是骨与关节感染的罕见病因。它难以培养,且毒性低于与原发性椎体骨髓炎相关的常见细菌。关于……骨髓炎或人工关节感染的病例报告很少,尤其是在男性中。……很少能在男性尿道定植,已知可在女性生殖泌尿系统的异物上形成生物膜。我们怀疑我们的患者输尿管支架发生了定植,使其易患骨髓炎。如果本病例不进行重复活检,我们的患者可能会出现经验性治疗失败。初次活检后停用抗生素证明非常有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a0f/11699804/bc4965c561e1/gr1.jpg

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