Yi Peiyu, Wu Yufeng, Wang Juntao, Liu Qilei, Xing Yafeng, Lu Yue, Ma Cunfei, Duan Liyuan, Zhao Jingnan, Meng Qingwei
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
State Key Laboratory of Fine Chemicals, Liaoning Provincial Key Laboratory of Chemical Safety and Emergency Technology, Department of Chemical Machinery and Safety, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China.
Org Biomol Chem. 2025 Feb 12;23(7):1574-1580. doi: 10.1039/d4ob01759e.
We report the first example of photocatalytic acceptorless dehydrogenation using cationic Eosin Y as a bifunctional photocatalyst, without metal catalysts or HAT reagents. Under Bayesian optimized conditions, a wide range of flavones were synthesized in moderate to excellent yields, many of which were reported with biological activities. Mechanistic studies suggest that flavones likely form through two HAT processes, with hydrogen release occurring photoredox.
我们报道了首例以阳离子曙红Y作为双功能光催化剂、无需金属催化剂或氢原子转移（HAT）试剂的光催化无受体脱氢反应。在贝叶斯优化条件下，以中等至优异的产率合成了多种黄酮类化合物，其中许多已报道具有生物活性。机理研究表明，黄酮类化合物可能通过两个氢原子转移过程形成，氢的释放发生在光氧化还原过程中。
