Ünlü Açıkel Sezin, Sadettin Burak Açıkel
Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Dermatology and Venerology, Ankara, Türkiye.
Ankara University Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Türkiye.
Clin Exp Dermatol. 2025 Jan 6. doi: 10.1093/ced/llae395.
Acne vulgaris has significant effects on the emotional and social wellbeing of an affected individual, leading to conditions like anxiety, depression and social isolation. Oral isotretinoin has been associated with various side-effects, including psychiatric concerns like depression and suicidal ideation. However, the connection between isotretinoin and these mental health issues remains controversial.
To provide an overview of the literature on the subject by investigating data such as the effects of articles in the field on the literature as a whole, coauthorship and citation analysis.
A bibliometric analysis was conducted using the Web of Science database to search for studies from 1986 to 2024 with keywords related to isotretinoin, suicide and depression. Data were analysed using VOSviewer software to visualize the bibliometric networks and trends.
For the study, 380 publications were identified, with a peak in 2018. The most common article types were original articles (60.3%), reviews (13.9%) and letters (12.1%). English is the predominant language of publication (93.4%). The h-index of these articles was 49, with an average of 23.0 citations per article. The top research areas included dermatology, pharmacology and psychiatry. The analysis highlights key authors and their contributions to the field.
The bibliometric analysis has revealed an evolving research landscape. The number of studies has increased since 2004, following the Food and Drug Administration's black box warning in 2005. While early studies linked isotretinoin to psychiatric issues, recent data have shown a stronger association between acne and these conditions rather than the medication itself. This analysis underscores the importance of continuous research and re-evaluation of clinical guidelines based on emerging evidence.
寻常痤疮对患者的情绪和社会幸福感有重大影响，会导致焦虑、抑郁和社会隔离等情况。口服异维A酸与多种副作用有关，包括抑郁和自杀意念等精神方面的问题。然而，异维A酸与这些心理健康问题之间的联系仍存在争议。
通过调查该领域文章对整体文献的影响、共同作者情况和引文分析等数据，对关于该主题的文献进行综述。
使用科学网数据库进行文献计量分析，以搜索1986年至2024年与异维A酸、自杀和抑郁相关的研究。使用VOSviewer软件分析数据，以可视化文献计量网络和趋势。
该研究共识别出380篇出版物，2018年达到峰值。最常见的文章类型是原创文章（60.3%）、综述（13.9%）和信函（12.1%）。英语是主要的出版语言（93.4%）。这些文章的h指数为49，平均每篇文章被引用23.0次。主要研究领域包括皮肤病学、药理学和精神病学。分析突出了关键作者及其对该领域的贡献。
文献计量分析揭示了一个不断演变的研究格局。自2005年美国食品药品监督管理局发布黑框警告后，2004年以来研究数量有所增加。虽然早期研究将异维A酸与精神问题联系起来，但最近的数据表明痤疮与这些情况之间的关联更强，而非药物本身。该分析强调了基于新出现的证据持续开展研究和重新评估临床指南的重要性。
