配体蛋白质组的系统蓝图。
A Systematic Blueprint to Ligand the Proteome.
作者信息
Calabrese Matthew F
机构信息
Discovery Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
出版信息
J Med Chem. 2025 Jan 23;68(2):1090-1091. doi: 10.1021/acs.jmedchem.4c03091. Epub 2025 Jan 6.
PMID:39761356
Abstract
The Target 2035 initiative is an ambitious proposal to discover pharmacological tools across the human proteome. This Viewpoint summarizes an approach inspired by that goal leveraging DNA-encoded library coupled with machine learning approaches to assess the ligandability of the WD40 repeat target class of proteins.
摘要
“2035目标”计划是一项旨在在整个人类蛋白质组中发现药理学工具的宏伟提议。本观点总结了一种受该目标启发的方法，该方法利用DNA编码文库结合机器学习方法来评估WD40重复蛋白靶标类别的配体可结合性。
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