Lu Tianyuan, Manousaki Despoina, Sun Lei, Paterson Andrew D
Department of Statistical Sciences, Faculty of Arts and Science, University of Toronto, Toronto, Ontario, Canada.
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI.
Diabetes. 2025 Apr 1;74(4):630-639. doi: 10.2337/db24-0380.
Identification of circulating proteins that may play a role in the pathogenesis of type 1 diabetes can provide promising targets for biomarker and drug target identification. Supported by multiple lines of evidence, circulating abundances of CTSH, IL27RA, SIRPG, and PGM1 were associated with the risk of type 1 diabetes. Tissues and cell types with enrichment of target protein-coding gene expression were identified. CTSH, IL27RA, SIRPG, and PGM1 may be explored as biomarkers or drug targets for type 1 diabetes.
鉴定可能在1型糖尿病发病机制中起作用的循环蛋白可为生物标志物和药物靶点的识别提供有前景的靶点。在多条证据的支持下，CTSH、IL27RA、SIRPG和PGM1的循环丰度与1型糖尿病风险相关。已确定了靶蛋白编码基因表达富集的组织和细胞类型。CTSH、IL27RA、SIRPG和PGM1可作为1型糖尿病的生物标志物或药物靶点进行探索。
