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白藜芦醇通过改变肠道微生物群和前列腺素D2含量增强α-PD-1的抗肿瘤作用。

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.

作者信息

Luo Baohua, An Qingling, Lei Jingyu, Tan Dengxu, Liu Xiaoqiu, Li Hui, Zhao Yong, Qin Jing, Zhang Caiqin, Zhang Yongbin, Shi Changhong

机构信息

Division of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.

Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, P.R. China.

出版信息

Gut Microbes. 2025 Dec;17(1):2447821. doi: 10.1080/19490976.2024.2447821. Epub 2024 Dec 30.

DOI:10.1080/19490976.2024.2447821

Abstract

The anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

摘要

抗程序性死亡蛋白1单克隆抗体（anti-PD-1 mAb）可与前列腺素D2（PGD2）或能促进PGD2合成的活性分子一起进一步考虑，以增强抗肿瘤免疫反应。

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Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.白藜芦醇通过改变肠道微生物群和前列腺素D2含量增强α-PD-1的抗肿瘤作用。

Gut Microbes. 2025 Dec;17(1):2447821. doi: 10.1080/19490976.2024.2447821. Epub 2024 Dec 30.

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