Effects of SKF 525-A, phenobarbital and 3-methylcholanthrene on the toxicity of lobeline sulfate.

Pretreatment of mice with the microsomal enzyme inducers and inhibitors modified the toxicity of lobeline sulfate. The intraperitoneal LD50 of lobeline sulfate following SKF 525-A (75 mg/kg), phenobarbital (PB), and 3-methylcholanthrene (3-MC) were 18.3, 85.5 and 82.1 mg/kg, respectively, as compared to that of saline treated controls, 55.3 mg/kg. Pretreatment of mice with disulfiram (DSF), diethylmaleate (DEM), or ethoxyquin hydrochloride (EQ-HC1) exhibited a very slight effect on the toxicity of lobeline sulfate. These results suggest that the hepatic microsomal monooxygenase system, but not glutathione (GSH), is involved in the detoxication of lobeline sulfate.