丁基羟基茴香醚、乙氧喹和双硫仑对小鼠急性吡咯里西啶生物碱中毒的保护作用。
Protective effects of butylated hydroxyanisole, ethoxyquin, and disulfiram on acute pyrrolizidine alkaloids poisoning in mice.
作者信息
Kim H L, Jones L P
出版信息
Res Commun Chem Pathol Pharmacol. 1982 May;36(2):341-4.
PMID:7100635
Abstract
Administration of butylated hydroxyanisole (BHA), ethoxyquin (EQ), and disulfiram (DSF) in the diet for 7 days reduced the acute toxicity of pyrrolizidine alkaloids isolated from Senecio longilobus. The LD50 values of the BHA- and EQ-fed mice were about twofold of the controls but the protective effect of DSF was inferior to that of either BHA or EQ.
摘要
在饮食中连续7天给予丁基羟基茴香醚（BHA）、乙氧喹（EQ）和双硫仑（DSF）可降低从长叶千里光中分离出的吡咯里西啶生物碱的急性毒性。喂食BHA和EQ的小鼠的半数致死量（LD50）值约为对照组的两倍，但DSF的保护作用不如BHA或EQ。
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