Alsfouk Bshra A, Al-Kuraishy Hayder M, Albuhadily Ali K, Al-Gareeb Ali I, Abdelaziz Ahmed M, Alexiou Athanasios, Papadakis Marios, Alruwaili Mubarak, Batiha Gaber El-Saber
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad 14132, Iraq.
Brain Res Bull. 2025 Feb;221:111189. doi: 10.1016/j.brainresbull.2025.111189. Epub 2025 Jan 4.
Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect the epileptogenesis and progression of disease. Therefore, repurposing of natural products with anti-inflammatory, anti-oxidant and anti-seizure effects such as berberine (BRB) may be logical in treating refractory epilepsy and TLE. However, the molecular mechanism of BRB against the development of epilepsy and progression of epileptic seizure mainly in TLE was not fully elucidated. Therefore, we attempt in this review to discuss the potential underlying molecular mechanism of BRB against the development and progression of epilepsy mainly the TLE.
癫痫是一种以无端反复癫痫发作为特征的神经系统疾病。颞叶癫痫（TLE）是成人中最常见的局灶性癫痫类型，对传统抗癫痫药物（ASM）耐药。有趣的是，ASM并不影响癫痫的发生和疾病进展。因此，重新利用具有抗炎、抗氧化和抗癫痫作用的天然产物（如黄连素，BRB）来治疗难治性癫痫和TLE可能是合理的。然而，BRB抗癫痫发生及癫痫发作进展（主要是在TLE中）的分子机制尚未完全阐明。因此，在本综述中，我们试图探讨BRB抗癫痫发生及进展（主要是TLE）的潜在分子机制。
