Yuan Yuan, Li Yuan, Zhang Hui, Zang Yajie, Liu Xiaonan, Hou Yue, Zhan Shuqin, Cai Yanning, Mao Wei, Chan Piu
Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China.
NPJ Parkinsons Dis. 2025 Jan 6;11(1):10. doi: 10.1038/s41531-024-00856-2.
This study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort. Patients with iRBD were enrolled and assessed for environmental factors and lifestyle using standardized structured questionnaires at baseline. All patients were prospectively followed for phenoconversion monitoring. The cumulative incidence was estimated using survival analysis. Of 155 iRBD enrolled in the cohort, follow-up information was available in 141 patients. The phenoconversion rate was 16.3% after 3 years, 27.6% after 5 years, and 57.2% after 10 years. Eighteen participants converted within 3 years, 27 converted within 5 years, and 36 converted within 10 years. IRBD with positive family history of parkinsonism had an increased risk of being converted to α-synucleinopathies, while tea drinking was associated with a decreased phenoconversion risk. Our findings shed light on a potential application of tea drinking in modifying iRBD progression.
本研究在中国队列中探讨了风险因素对特发性快速眼动（REM）睡眠行为障碍（iRBD）进展为α-突触核蛋白病的影响。纳入iRBD患者，并在基线时使用标准化结构化问卷对环境因素和生活方式进行评估。所有患者均进行前瞻性随访以监测表型转换。使用生存分析估计累积发病率。该队列纳入的155例iRBD患者中，141例患者有随访信息。3年后表型转换率为16.3%，5年后为27.6%，10年后为57.2%。18名参与者在3年内发生转换，27名在5年内发生转换，36名在10年内发生转换。有帕金森病家族史阳性的iRBD患者转换为α-突触核蛋白病的风险增加，而饮茶与表型转换风险降低相关。我们的研究结果为饮茶在改变iRBD进展方面的潜在应用提供了线索。
