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从神经疾病研究视角看多发性硬化的病理学与发病机制

[Pathology and pathogenesis of multiple sclerosis from the viewpoint of neurologic disease research].

作者信息

Seitelberger F

出版信息

Wien Med Wochenschr. 1985 Jan 31;135(1-2):6-7.

PMID:3976241
Abstract

The pathology of multiple sclerosis (MS) is characterized by the trias: inflammation, primary demyelination and reactive gliosis. However, besides these obligatory alterations a high inter- and intraindividual variability of structural aspects is found in MS lesions. Recent experimental studies in a model disease for MS, in chronic relapsing experimental allergic encephalomyelitis, provide a better understanding of the dynamics of lesions development in MS brains.

摘要

多发性硬化症(MS)的病理学特征为三联征:炎症、原发性脱髓鞘和反应性胶质增生。然而,除了这些必然出现的改变外,在MS病灶中还发现结构方面存在高度的个体间和个体内变异性。最近在MS的一种模型疾病——慢性复发性实验性变应性脑脊髓炎中的实验研究,使人们对MS脑内病灶发展的动态变化有了更好的理解。

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