[Pathology and pathogenesis of multiple sclerosis from the viewpoint of neurologic disease research].

The pathology of multiple sclerosis (MS) is characterized by the trias: inflammation, primary demyelination and reactive gliosis. However, besides these obligatory alterations a high inter- and intraindividual variability of structural aspects is found in MS lesions. Recent experimental studies in a model disease for MS, in chronic relapsing experimental allergic encephalomyelitis, provide a better understanding of the dynamics of lesions development in MS brains.