Alshiekh Ali, Hadakie Rana, Al Kurdi M Fadi, Sukkar Luna, Alhalabi Marwan, Hamed Hamoud
Department of Surgery, Faculty of Medicine, Damascus University, Damascus, Syrian Arab Republic.
Al-Assad University Hospital, Damascus University, Damascus, Syrian Arab Republic.
Sci Rep. 2025 Jan 6;15(1):987. doi: 10.1038/s41598-025-85544-8.
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age worldwide, and its related features like obesity, mental health issues and hyperandrogenism may contribute to inadequately investigated health problems such as sexual dysfunction (SD) and lower urinary tract symptoms (LUTS). Therefore, this study examined the impact of PCOS on sexual function (SF) and lower urinary tract in Syrian women by recruiting a total of 178 women of reproductive age, of whom 88 were diagnosed with PCOS according to the Rotterdam criteria and 90 without PCOS were considered as the control group. Female sexual function index (FSFI) and Bristol Female Lower Urinary Tract Symptom Questionnaire (BFLUTS) were used to assess SF and LUTS respectively. PCOS group had higher SD prevalence compared to control group (65.9% vs 48.9%, p = 0.016), and BMI showed an inverse correlation with the total FSFI score in PCOS group (p = 0.027, r = -0.235). Furthermore, PCOS group exhibited significantly lower scores in orgasm and satisfaction subdomains. Additionally, PCOS patients had significantly higher total BFLUTS score compared to control group (median 8 vs 5, p = 0.025). Thus, PCOS may be related to SD and LUTS, highlighting the importance of evaluating SF and urinary symptoms in PCOS patients.
多囊卵巢综合征（PCOS）是全球育龄女性中最常见的内分泌紊乱疾病，其相关特征如肥胖、心理健康问题和高雄激素血症可能导致诸如性功能障碍（SD）和下尿路症状（LUTS）等未得到充分研究的健康问题。因此，本研究通过招募总共178名育龄女性来考察PCOS对叙利亚女性性功能（SF）和下尿路的影响，其中88名根据鹿特丹标准被诊断为PCOS，90名无PCOS的女性被视为对照组。分别使用女性性功能指数（FSFI）和布里斯托尔女性下尿路症状问卷（BFLUTS）来评估SF和LUTS。与对照组相比，PCOS组的SD患病率更高（65.9%对48.9%，p = 0.016），且PCOS组中BMI与FSFI总分呈负相关（p = 0.027，r = -0.235）。此外，PCOS组在性高潮和满意度子领域的得分显著更低。另外，与对照组相比，PCOS患者的BFLUTS总分显著更高（中位数8对5，p = 0.025）。因此，PCOS可能与SD和LUTS有关，突出了评估PCOS患者SF和尿路症状的重要性。
