Biotechnology Program, Department of Mathematics and Natural Sciences, School of Data and Sciences, Brac University, Dhaka, Bangladesh.
Microbiology Program, Department of Mathematics and Natural Sciences, School of Data and Sciences, Brac University, Dhaka, Bangladesh.
Womens Health (Lond). 2022 Jan-Dec;18:17455057221117966. doi: 10.1177/17455057221117966.
Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, which is still incurable. However, the symptoms can be successfully managed with proper medication and lifestyle interventions. Despite its prevalence, little is known about its etiology. In this review article, the up-to-date diagnostic features and parameters recommended on the grounds of evidence-based data and different guidelines are explored. The ambiguity and insufficiency of data when diagnosing adolescent women have been put under special focus. We look at some of the most recent research done to establish relationships between different gene polymorphisms with polycystic ovary syndrome in various populations along with the underestimated impact of environmental factors like endocrine-disrupting chemicals on the reproductive health of these women. Furthermore, the article concludes with existing treatments options and the scopes for advancement in the near future. Various therapies have been considered as potential treatment through multiple randomized controlled studies, and clinical trials conducted over the years are described in this article. Standard therapies ranging from metformin to newly found alternatives based on vitamin D and gut microbiota could shine some light and guidance toward a permanent cure for this female reproductive health issue in the future.
多囊卵巢综合征是育龄妇女中最常见的内分泌紊乱疾病，目前仍无法治愈。然而，通过适当的药物治疗和生活方式干预，可以成功地控制其症状。尽管其发病率很高，但人们对其病因知之甚少。在这篇综述文章中，我们探讨了基于循证数据和不同指南推荐的最新诊断特征和参数。特别关注了在诊断青春期女性时数据的模糊性和不足。我们研究了一些最近的研究，以确定不同人群中多囊卵巢综合征与不同基因多态性之间的关系，以及环境因素（如内分泌干扰化学物质）对这些女性生殖健康的被低估的影响。此外，本文还总结了现有的治疗选择和未来的发展前景。通过多项随机对照研究，已经考虑了多种治疗方法，本文描述了多年来进行的临床试验。从二甲双胍到基于维生素 D 和肠道微生物群的新发现的替代方法，各种标准疗法都被认为是潜在的治疗方法，这为未来针对这种女性生殖健康问题的永久性治疗提供了一些启示和指导。
