You Qiuting, Chen Yanbo, Yang Doudou, Shen Shiyu, Chen Yi, Zhai Yinglin, Zeng Minhua, Wang Mingyi, Kang Tao, Su Fengxi
S' Clinic, Guangzhou, 510000, China.
Trauma Orthopedics, Foot & Ankle Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510000, China.
Support Care Cancer. 2025 Jan 7;33(2):74. doi: 10.1007/s00520-024-09118-6.
This study aims to explore the effects of Tai Chi Chuan (TCC) on physical function, hematological metabolic biomarkers, sleep quality, and mental health in breast cancer patients.
This was a prospective clinical trial that involved 37 breast cancer patients who had completed surgery treatment. Participants' motor function, hematological examination, and self-rated questionnaire were assessed at the baseline and after the intervention.
Through the 12-week TCC intervention, participants' weights (p = 0.981), body mass index (BMI) (p = 0.913), and blood pressure (p = 0.374 for systolic BP, p = 0.299 for diastolic BP) remained stable; waist-hip ratio significantly decreased (p < 0.001); and post-intervention pulse rate (p = 0.011) and vital capacity (p = 0.062) slightly increased. In the aspect of motor function, the value of sit and reach (p < 0.001), grip strength of both hands (p < 0.001), and most active range of motion of neck and shoulder joint (p < 0.001 for anteflexion and both left and right lateroflexion of neck joint, both left and right adduction and rear protraction of shoulder joint) increased after intervention. Arm girth (p < 0.05 for arm girth in left styloid process of ulna, 5 cm below left cubital crease, left and right cubital crease, 10 cm above left and right cubital crease, and left axilla) showed a shrinking trend after intervention. According to the questionnaire of Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HADS), participants' sleep quality improved, and anxiety and depression remained stable after the trial (p = 0.021 for PSQI, p = 0.631 for anxiety, p = 0.182 for depression). Hematological examination of total protein (p = 0.016), albumin (p < 0.001), albumin-globulin ratio (A/G) (p < 0.001), high-density lipoprotein cholesterol (HDL-CH) (p = 0.002), and apolipoprotein A1 (APOA1) (p < 0.001) increased after intervention.
Motor function and sleep quality improved significantly after TCC intervention for 3 months in breast cancer patients. At the same time, some hematological metabolic biomarkers also changed better.
ChiCTR2200061422. Date of registration: June 24th, 2022.
本研究旨在探讨太极拳（TCC）对乳腺癌患者身体功能、血液代谢生物标志物、睡眠质量和心理健康的影响。
这是一项前瞻性临床试验，纳入了37例完成手术治疗的乳腺癌患者。在基线和干预后对参与者的运动功能、血液检查和自评问卷进行评估。
经过12周的太极拳干预，参与者的体重（p = 0.981）、体重指数（BMI）（p = 0.913）和血压（收缩压p = 0.374，舒张压p = 0.299）保持稳定；腰臀比显著降低（p < 0.001）；干预后的脉搏率（p = 0.011）和肺活量（p = 0.062）略有增加。在运动功能方面，干预后坐立前屈值（p < 0.001）、双手握力（p < 0.001）以及颈部和肩关节的最大活动范围（颈部前屈、左右侧屈，肩关节左右内收和后伸，p均< 0.001）均增加。干预后上臂围（尺骨茎突左侧、左肘横纹下5 cm、左右肘横纹、左右肘横纹上10 cm和左腋窝处的上臂围，p < 0.05）呈缩小趋势。根据匹兹堡睡眠质量指数（PSQI）问卷和医院焦虑抑郁量表（HADS），参与者的睡眠质量得到改善，试验后焦虑和抑郁保持稳定（PSQI p = 0.021，焦虑p = 0.631，抑郁p = 0.182）。干预后血液检查中总蛋白（p = 0.016）、白蛋白（p < 0.001）、白蛋白球蛋白比值（A/G）（p < 0.001）、高密度脂蛋白胆固醇（HDL-CH）（p = 0.002）和载脂蛋白A1（APOA1）（p < 0.001）升高。
乳腺癌患者进行3个月的太极拳干预后，运动功能和睡眠质量显著改善。同时，一些血液代谢生物标志物也有更好的变化。
ChiCTR2200061422。注册日期：2022年6月24日。
